ZG16 protein (Homo sapiens) - STRING network view

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ZG16

zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (167 aa)

Predicted Functional Partners:

AHSG

0.809

APOD

0.806

HORMAD1

0.700

PI15

0.670

SYCN

0.503

GP2

0.488

AADACL2

0.459

CUZD1

0.416

CHP2

0.412

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADACL2	ZG16	ENSP00000348911	ENSP00000383563	arylacetamide deacetylase-like 2	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.459
AHSG	ZG16	ENSP00000393887	ENSP00000383563	alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.809
APOD	ZG16	ENSP00000345179	ENSP00000383563	apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.806
CHP2	ZG16	ENSP00000300113	ENSP00000383563	calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...]	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.412
CUZD1	ZG16	ENSP00000357900	ENSP00000383563	CUB and zona pellucida-like domains 1	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.416
GP2	ZG16	ENSP00000370767	ENSP00000383563	glycoprotein 2 (zymogen granule membrane)	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.488
HORMAD1	ZG16	ENSP00000355167	ENSP00000383563	HORMA domain containing 1	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.700
PI15	ZG16	ENSP00000260113	ENSP00000383563	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.670
SYCN	ZG16	ENSP00000325564	ENSP00000383563	syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity)	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	0.503
ZG16	AADACL2	ENSP00000383563	ENSP00000348911	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	arylacetamide deacetylase-like 2	0.459
ZG16	AHSG	ENSP00000383563	ENSP00000393887	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions	0.809
ZG16	APOD	ENSP00000383563	ENSP00000345179	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts	0.806
ZG16	CHP2	ENSP00000383563	ENSP00000300113	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...]	0.412
ZG16	CUZD1	ENSP00000383563	ENSP00000357900	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	CUB and zona pellucida-like domains 1	0.416
ZG16	GP2	ENSP00000383563	ENSP00000370767	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	glycoprotein 2 (zymogen granule membrane)	0.488
ZG16	HORMAD1	ENSP00000383563	ENSP00000355167	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	HORMA domain containing 1	0.700
ZG16	PI15	ENSP00000383563	ENSP00000260113	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin	0.670
ZG16	SYCN	ENSP00000383563	ENSP00000325564	zymogen granule protein 16 homolog (rat); May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN	syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity)	0.503

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