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STRINGSTRING
GRHL2 GRHL2 GRHL1 GRHL1 MMAA MMAA LMBRD1 LMBRD1 MMACHC MMACHC MUT MUT MTRR MTRR MMADHC MMADHC MMAB MMAB ABCD4 ABCD4 MTR MTR
"MMACHC" - methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria in Homo sapiens
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MMACHCmethylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) (282 aa)    
Predicted Functional Partners:
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism (296 aa)
         score_image score_image score_image   0.998
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) (1265 aa)
         score_image score_image score_image   0.973
LMBRD1
LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) (540 aa)
           score_image score_image   0.966
MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state (725 aa)
           score_image score_image   0.948
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type; Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (418 aa)
       score_image     score_image   0.810
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type (250 aa)
             score_image   0.797
MUT
methylmalonyl CoA mutase; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (750 aa)
             score_image   0.759
GRHL1
grainyhead-like 1 (Drosophila) (618 aa)
             score_image   0.759
GRHL2
grainyhead-like 2 (Drosophila); May function as a transcription factor (625 aa)
             score_image   0.758
ABCD4
ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm (606 aa)
             score_image   0.679
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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