LIPM protein (Homo sapiens) - STRING network view

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LIPM

lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (423 aa)

Predicted Functional Partners:

ALAS2

0.629

ALAS1

0.629

SPTLC3

0.601

GCAT

0.601

SPTLC1

0.601

SPTLC2

0.601

AP3D1

0.586

SYT14

0.580

PTPN1

0.573

PHF8

0.550

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALAS1	ALAS2	ENSP00000309259	ENSP00000332369	aminolevulinate, delta-, synthase 1	aminolevulinate, delta-, synthase 2	0.807
ALAS1	GCAT	ENSP00000309259	ENSP00000371110	aminolevulinate, delta-, synthase 1	glycine C-acetyltransferase	0.912
ALAS1	LIPM	ENSP00000309259	ENSP00000383901	aminolevulinate, delta-, synthase 1	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.629
ALAS2	ALAS1	ENSP00000332369	ENSP00000309259	aminolevulinate, delta-, synthase 2	aminolevulinate, delta-, synthase 1	0.807
ALAS2	GCAT	ENSP00000332369	ENSP00000371110	aminolevulinate, delta-, synthase 2	glycine C-acetyltransferase	0.909
ALAS2	LIPM	ENSP00000332369	ENSP00000383901	aminolevulinate, delta-, synthase 2	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.629
AP3D1	LIPM	ENSP00000344055	ENSP00000383901	adaptor-related protein complex 3, delta 1 subunit; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.586
GCAT	ALAS1	ENSP00000371110	ENSP00000309259	glycine C-acetyltransferase	aminolevulinate, delta-, synthase 1	0.912
GCAT	ALAS2	ENSP00000371110	ENSP00000332369	glycine C-acetyltransferase	aminolevulinate, delta-, synthase 2	0.909
GCAT	LIPM	ENSP00000371110	ENSP00000383901	glycine C-acetyltransferase	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.601
LIPM	ALAS1	ENSP00000383901	ENSP00000309259	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	aminolevulinate, delta-, synthase 1	0.629
LIPM	ALAS2	ENSP00000383901	ENSP00000332369	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	aminolevulinate, delta-, synthase 2	0.629
LIPM	AP3D1	ENSP00000383901	ENSP00000344055	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	adaptor-related protein complex 3, delta 1 subunit; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals	0.586
LIPM	GCAT	ENSP00000383901	ENSP00000371110	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	glycine C-acetyltransferase	0.601
LIPM	PHF8	ENSP00000383901	ENSP00000350676	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	PHD finger protein 8	0.550
LIPM	PTPN1	ENSP00000383901	ENSP00000360683	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	protein tyrosine phosphatase, non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion	0.573
LIPM	SPTLC1	ENSP00000383901	ENSP00000262554	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...]	0.601
LIPM	SPTLC2	ENSP00000383901	ENSP00000216484	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate	0.601
LIPM	SPTLC3	ENSP00000383901	ENSP00000381968	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference	0.601
LIPM	SYT14	ENSP00000383901	ENSP00000389039	lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	synaptotagmin XIV	0.580

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