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STRINGSTRING
HOXC11 HOXC11 HOXC9 HOXC9 ENSG00000257184 ENSG00000257184 HOXD12 HOXD12 DMRTA2 DMRTA2 HOXD13 HOXD13 HOXA9 HOXA9 NEUROG1 NEUROG1 TXNL1 TXNL1 HOXC10 HOXC10 HOXB9 HOXB9
"DMRTA2" - DMRT-like family A2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DMRTA2DMRT-like family A2; May be involved in sexual development (542 aa)    
Predicted Functional Partners:
NEUROG1
neurogenin 1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity) (237 aa)
            score_image   0.839
TXNL1
thioredoxin-like 1; Active thioredoxin with a redox potential of about -250 mV (289 aa)
            score_image   0.615
HOXC11
homeobox C11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene (304 aa)
            score_image   0.575
ENSG00000257184
Uncharacterized protein (112 aa)
            score_image   0.575
HOXD12
homeobox D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (270 aa)
            score_image   0.575
HOXD13
homeobox D13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (343 aa)
            score_image   0.575
HOXA9
homeobox A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (272 aa)
            score_image   0.575
HOXB9
homeobox B9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (250 aa)
            score_image   0.575
HOXC10
homeobox C10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (342 aa)
            score_image   0.575
HOXC9
homeobox C9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (260 aa)
            score_image   0.575
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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