LIPN protein (Homo sapiens) - STRING network view

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Score

LIPN

lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (398 aa)

Predicted Functional Partners:

SP6

0.870

PCSK5

0.830

SP9

0.810

CYP4F22

0.738

MARVELD1

0.728

LRP5

0.725

ACRV1

0.705

MTRNR2L5

0.636

ALAS2

0.629

ALAS1

0.629

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACRV1	LIPN	ENSP00000432816	ENSP00000383923	acrosomal vesicle protein 1	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.705
ACRV1	LRP5	ENSP00000432816	ENSP00000294304	acrosomal vesicle protein 1	low density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...]	0.472
ACRV1	SP6	ENSP00000432816	ENSP00000340799	acrosomal vesicle protein 1	Sp6 transcription factor; Promotes cell proliferation (By similarity)	0.726
ACRV1	SP9	ENSP00000432816	ENSP00000378418	acrosomal vesicle protein 1	Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)	0.871
ALAS1	ALAS2	ENSP00000309259	ENSP00000332369	aminolevulinate, delta-, synthase 1	aminolevulinate, delta-, synthase 2	0.807
ALAS1	LIPN	ENSP00000309259	ENSP00000383923	aminolevulinate, delta-, synthase 1	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.629
ALAS2	ALAS1	ENSP00000332369	ENSP00000309259	aminolevulinate, delta-, synthase 2	aminolevulinate, delta-, synthase 1	0.807
ALAS2	LIPN	ENSP00000332369	ENSP00000383923	aminolevulinate, delta-, synthase 2	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.629
CYP4F22	LIPN	ENSP00000269703	ENSP00000383923	cytochrome P450, family 4, subfamily F, polypeptide 22	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	0.738
LIPN	ACRV1	ENSP00000383923	ENSP00000432816	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	acrosomal vesicle protein 1	0.705
LIPN	ALAS1	ENSP00000383923	ENSP00000309259	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	aminolevulinate, delta-, synthase 1	0.629
LIPN	ALAS2	ENSP00000383923	ENSP00000332369	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	aminolevulinate, delta-, synthase 2	0.629
LIPN	CYP4F22	ENSP00000383923	ENSP00000269703	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	cytochrome P450, family 4, subfamily F, polypeptide 22	0.738
LIPN	LRP5	ENSP00000383923	ENSP00000294304	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	low density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...]	0.725
LIPN	MARVELD1	ENSP00000383923	ENSP00000441365	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	MARVEL domain containing 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (By similarity)	0.728
LIPN	MTRNR2L5	ENSP00000383923	ENSP00000437910	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	MT-RNR2-like 5; Plays a role as a neuroprotective and antiapoptotic factor	0.636
LIPN	PCSK5	ENSP00000383923	ENSP00000446280	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	0.830
LIPN	SP6	ENSP00000383923	ENSP00000340799	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	Sp6 transcription factor; Promotes cell proliferation (By similarity)	0.870
LIPN	SP9	ENSP00000383923	ENSP00000378418	lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers	Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)	0.810
LRP5	ACRV1	ENSP00000294304	ENSP00000432816	low density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...]	acrosomal vesicle protein 1	0.472

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