node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHMT1 | SETD5 | ENSP00000417980 | ENSP00000383939 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | SET domain containing 5 | 0.453 |
EHMT1 | SETD7 | ENSP00000417980 | ENSP00000274031 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] | 0.643 |
EHMT1 | SMYD4 | ENSP00000417980 | ENSP00000304360 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | SET and MYND domain containing 4 | 0.487 |
SETD3 | SETD5 | ENSP00000327436 | ENSP00000383939 | SET domain containing 3 | SET domain containing 5 | 0.470 |
SETD4 | SETD5 | ENSP00000329189 | ENSP00000383939 | SET domain containing 4 | SET domain containing 5 | 0.816 |
SETD4 | SETD6 | ENSP00000329189 | ENSP00000219315 | SET domain containing 4 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.774 |
SETD4 | SETD7 | ENSP00000329189 | ENSP00000274031 | SET domain containing 4 | SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] | 0.456 |
SETD4 | SMYD4 | ENSP00000329189 | ENSP00000304360 | SET domain containing 4 | SET and MYND domain containing 4 | 0.400 |
SETD5 | EHMT1 | ENSP00000383939 | ENSP00000417980 | SET domain containing 5 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | 0.453 |
SETD5 | SETD3 | ENSP00000383939 | ENSP00000327436 | SET domain containing 5 | SET domain containing 3 | 0.470 |
SETD5 | SETD4 | ENSP00000383939 | ENSP00000329189 | SET domain containing 5 | SET domain containing 4 | 0.816 |
SETD5 | SETD6 | ENSP00000383939 | ENSP00000219315 | SET domain containing 5 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.657 |
SETD5 | SETD7 | ENSP00000383939 | ENSP00000274031 | SET domain containing 5 | SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] | 0.609 |
SETD5 | SMYD4 | ENSP00000383939 | ENSP00000304360 | SET domain containing 5 | SET and MYND domain containing 4 | 0.434 |
SETD5 | THUMPD3 | ENSP00000383939 | ENSP00000339532 | SET domain containing 5 | THUMP domain containing 3 | 0.504 |
SETD6 | SETD4 | ENSP00000219315 | ENSP00000329189 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | SET domain containing 4 | 0.774 |
SETD6 | SETD5 | ENSP00000219315 | ENSP00000383939 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | SET domain containing 5 | 0.657 |
SETD6 | SETD7 | ENSP00000219315 | ENSP00000274031 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] | 0.492 |
SETD7 | EHMT1 | ENSP00000274031 | ENSP00000417980 | SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | 0.643 |
SETD7 | SETD4 | ENSP00000274031 | ENSP00000329189 | SET domain containing (lysine methyltransferase) 7; Histone methyltransferase that specifically monomethylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylat [...] | SET domain containing 4 | 0.456 |