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SHC1 SHC1 JAK2 JAK2 LYN LYN PTPN11 PTPN11 IL3RA IL3RA CSF2 CSF2 CSF2RA CSF2RA CSF2RB CSF2RB IL3 IL3 IL5RA IL5RA IL5 IL5
"CSF2RB" - colony stimulating factor 2 receptor, beta, low-affinity in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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textmining
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protein homology
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Score
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor (897 aa)    
Predicted Functional Partners:
JAK2
Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] (1132 aa)
        score_image score_image score_image   0.999
CSF2
colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes (144 aa)
        score_image score_image score_image   0.999
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (434 aa)
        score_image score_image score_image   0.998
IL3
interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages (152 aa)
        score_image score_image score_image   0.998
SHC1
SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
        score_image score_image score_image   0.997
IL5RA
interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 (420 aa)
        score_image score_image score_image   0.992
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (593 aa)
        score_image score_image score_image   0.991
IL5
interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells (134 aa)
        score_image score_image score_image   0.990
IL3RA
interleukin 3 receptor, alpha (low affinity); This is a receptor for interleukin-3 (378 aa)
        score_image score_image score_image   0.987
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] (512 aa)
        score_image score_image score_image   0.983
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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