node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF2 | CSF2RA | ENSP00000296871 | ENSP00000394227 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.999 |
CSF2 | CSF2RB | ENSP00000296871 | ENSP00000384053 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | 0.999 |
CSF2 | IL3 | ENSP00000296871 | ENSP00000296870 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages | 0.996 |
CSF2 | IL3RA | ENSP00000296871 | ENSP00000327890 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 3 receptor, alpha (low affinity); This is a receptor for interleukin-3 | 0.954 |
CSF2 | IL5 | ENSP00000296871 | ENSP00000231454 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells | 0.962 |
CSF2 | IL5RA | ENSP00000296871 | ENSP00000256452 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 | 0.976 |
CSF2 | JAK2 | ENSP00000296871 | ENSP00000371067 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.993 |
CSF2 | LYN | ENSP00000296871 | ENSP00000428924 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] | 0.944 |
CSF2 | PTPN11 | ENSP00000296871 | ENSP00000340944 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.988 |
CSF2 | SHC1 | ENSP00000296871 | ENSP00000401303 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | SHC (Src homology 2 domain containing) transforming protein 1 | 0.947 |
CSF2RA | CSF2 | ENSP00000394227 | ENSP00000296871 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | 0.999 |
CSF2RA | CSF2RB | ENSP00000394227 | ENSP00000384053 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | 0.998 |
CSF2RA | IL3 | ENSP00000394227 | ENSP00000296870 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages | 0.918 |
CSF2RA | IL5 | ENSP00000394227 | ENSP00000231454 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells | 0.889 |
CSF2RA | JAK2 | ENSP00000394227 | ENSP00000371067 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.939 |
CSF2RA | LYN | ENSP00000394227 | ENSP00000428924 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] | 0.962 |
CSF2RA | PTPN11 | ENSP00000394227 | ENSP00000340944 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.921 |
CSF2RA | SHC1 | ENSP00000394227 | ENSP00000401303 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | SHC (Src homology 2 domain containing) transforming protein 1 | 0.928 |
CSF2RB | CSF2 | ENSP00000384053 | ENSP00000296871 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | 0.999 |
CSF2RB | CSF2RA | ENSP00000384053 | ENSP00000394227 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.998 |