MEI1 protein (Homo sapiens) - STRING network view

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MEI1

meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) (1274 aa)

Predicted Functional Partners:

MORC1

0.756

NEDD8

0.709

SPO11

0.680

ENSG00000262314

0.663

NAE1

0.662

UBE2M

0.661

SPATA17

0.616

CCDC36

0.616

SYCE2

0.609

PSMD14

0.606

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC36	ENSG00000262314	ENSP00000296449	ENSP00000459356	coiled-coil domain containing 36	Spermatogenesis-associated protein 22; Uncharacterized protein	0.406
CCDC36	MEI1	ENSP00000296449	ENSP00000384115	coiled-coil domain containing 36	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	0.616
CCDC36	SYCE2	ENSP00000296449	ENSP00000293695	coiled-coil domain containing 36	synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity)	0.585
ENSG00000262314	CCDC36	ENSP00000459356	ENSP00000296449	Spermatogenesis-associated protein 22; Uncharacterized protein	coiled-coil domain containing 36	0.406
ENSG00000262314	MEI1	ENSP00000459356	ENSP00000384115	Spermatogenesis-associated protein 22; Uncharacterized protein	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	0.663
ENSG00000262314	SPO11	ENSP00000459356	ENSP00000360310	Spermatogenesis-associated protein 22; Uncharacterized protein	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity)	0.434
MEI1	CCDC36	ENSP00000384115	ENSP00000296449	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	coiled-coil domain containing 36	0.616
MEI1	ENSG00000262314	ENSP00000384115	ENSP00000459356	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	Spermatogenesis-associated protein 22; Uncharacterized protein	0.663
MEI1	MORC1	ENSP00000384115	ENSP00000232603	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.756
MEI1	NAE1	ENSP00000384115	ENSP00000290810	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	NEDD8 activating enzyme E1 subunit 1; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation	0.662
MEI1	NEDD8	ENSP00000384115	ENSP00000250495	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins	0.709
MEI1	PSMD14	ENSP00000384115	ENSP00000386541	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; Metalloprotease component of the 26S proteasome that specifically cleaves ’Lys-63’-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs)- acts as a regulator of non-homologous end joining (NHEJ) by cleaving ’Lys-63’-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading	0.606
MEI1	SPATA17	ENSP00000384115	ENSP00000355900	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	spermatogenesis associated 17	0.616
MEI1	SPO11	ENSP00000384115	ENSP00000360310	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity)	0.680
MEI1	SYCE2	ENSP00000384115	ENSP00000293695	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity)	0.609
MEI1	UBE2M	ENSP00000384115	ENSP00000253023	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	ubiquitin-conjugating enzyme E2M; Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation	0.661
MORC1	MEI1	ENSP00000232603	ENSP00000384115	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	0.756
MORC1	SPO11	ENSP00000232603	ENSP00000360310	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity)	0.607
NAE1	MEI1	ENSP00000290810	ENSP00000384115	NEDD8 activating enzyme E1 subunit 1; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	0.662
NAE1	NEDD8	ENSP00000290810	ENSP00000250495	NEDD8 activating enzyme E1 subunit 1; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation	neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins	0.998

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