FBLN2 protein (Homo sapiens) - STRING network view

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FBLN2

fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent (1231 aa)

Predicted Functional Partners:

LAMA1

0.963

HSPG2

0.961

VCAN

0.957

MFAP2

0.948

MFAP5

0.944

MFAP4

0.917

MFAP1

0.915

EFEMP1

0.910

FBLN5

0.909

EFEMP2

0.909

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFEMP1	EFEMP2	ENSP00000347596	ENSP00000309953	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	EGF containing fibulin-like extracellular matrix protein 2	0.902
EFEMP1	FBLN2	ENSP00000347596	ENSP00000384169	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	0.910
EFEMP1	FBLN5	ENSP00000347596	ENSP00000345008	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling	0.904
EFEMP1	MFAP1	ENSP00000347596	ENSP00000267812	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.921
EFEMP1	MFAP2	ENSP00000347596	ENSP00000364685	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	microfibrillar-associated protein 2; Component of the elastin-associated microfibrils	0.927
EFEMP1	MFAP4	ENSP00000347596	ENSP00000378957	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions	0.905
EFEMP1	MFAP5	ENSP00000347596	ENSP00000352455	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	microfibrillar associated protein 5; Component of the elastin-associated microfibrils	0.922
EFEMP2	EFEMP1	ENSP00000309953	ENSP00000347596	EGF containing fibulin-like extracellular matrix protein 2	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	0.902
EFEMP2	FBLN2	ENSP00000309953	ENSP00000384169	EGF containing fibulin-like extracellular matrix protein 2	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	0.909
EFEMP2	FBLN5	ENSP00000309953	ENSP00000345008	EGF containing fibulin-like extracellular matrix protein 2	fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling	0.957
EFEMP2	MFAP1	ENSP00000309953	ENSP00000267812	EGF containing fibulin-like extracellular matrix protein 2	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.920
EFEMP2	MFAP2	ENSP00000309953	ENSP00000364685	EGF containing fibulin-like extracellular matrix protein 2	microfibrillar-associated protein 2; Component of the elastin-associated microfibrils	0.936
EFEMP2	MFAP4	ENSP00000309953	ENSP00000378957	EGF containing fibulin-like extracellular matrix protein 2	microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions	0.905
EFEMP2	MFAP5	ENSP00000309953	ENSP00000352455	EGF containing fibulin-like extracellular matrix protein 2	microfibrillar associated protein 5; Component of the elastin-associated microfibrils	0.931
FBLN2	EFEMP1	ENSP00000384169	ENSP00000347596	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth	0.910
FBLN2	EFEMP2	ENSP00000384169	ENSP00000309953	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	EGF containing fibulin-like extracellular matrix protein 2	0.909
FBLN2	FBLN5	ENSP00000384169	ENSP00000345008	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling	0.909
FBLN2	HSPG2	ENSP00000384169	ENSP00000363827	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	0.961
FBLN2	LAMA1	ENSP00000384169	ENSP00000374309	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	laminin, alpha 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components	0.963
FBLN2	MFAP1	ENSP00000384169	ENSP00000267812	fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.915

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