| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACPP | ACY1 | ENSP00000323036 | ENSP00000384296 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | 0.595 |
| ACPP | ASPA | ENSP00000323036 | ENSP00000263080 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.486 |
| ACY1 | ACPP | ENSP00000384296 | ENSP00000323036 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.595 |
| ACY1 | APEH | ENSP00000384296 | ENSP00000296456 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser | 0.745 |
| ACY1 | ASPA | ENSP00000384296 | ENSP00000263080 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.883 |
| ACY1 | GLB1 | ENSP00000384296 | ENSP00000306920 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.758 |
| ACY1 | NAGS | ENSP00000384296 | ENSP00000293404 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity | 0.616 |
| ACY1 | NUDT1 | ENSP00000384296 | ENSP00000339503 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | nudix (nucleoside diphosphate linked moiety X)-type motif 1; Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A-T to C-G and G-C to T-A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | 0.613 |
| ACY1 | OTC | ENSP00000384296 | ENSP00000039007 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | ornithine carbamoyltransferase | 0.605 |
| ACY1 | SPHK1 | ENSP00000384296 | ENSP00000313681 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol | 0.958 |
| ACY1 | TTC1 | ENSP00000384296 | ENSP00000231238 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | tetratricopeptide repeat domain 1 | 0.826 |
| ACY1 | UBC | ENSP00000384296 | ENSP00000344818 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | ubiquitin C | 0.755 |
| APEH | ACY1 | ENSP00000296456 | ENSP00000384296 | N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | 0.745 |
| APEH | ASPA | ENSP00000296456 | ENSP00000263080 | N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.440 |
| APEH | GLB1 | ENSP00000296456 | ENSP00000306920 | N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.483 |
| APEH | UBC | ENSP00000296456 | ENSP00000344818 | N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser | ubiquitin C | 0.964 |
| ASPA | ACPP | ENSP00000263080 | ENSP00000323036 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.486 |
| ASPA | ACY1 | ENSP00000263080 | ENSP00000384296 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) | 0.883 |
| ASPA | APEH | ENSP00000263080 | ENSP00000296456 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | N-acylaminoacyl-peptide hydrolase; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser | 0.440 |
| ASPA | GLB1 | ENSP00000263080 | ENSP00000306920 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.440 |
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