TRIOBP protein (Homo sapiens) - STRING network view

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TRIOBP

TRIO and F-actin binding protein (2365 aa)

Predicted Functional Partners:

HECTD3

0.576

UBC

0.576

PLK1

0.576

TERF1

0.576

PLEK

0.560

DBR1

0.528

ACTN1

0.511

PLS1

0.507

ESPN

0.476

DFNB59

0.471

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	PLEK	ENSP00000377941	ENSP00000234313	actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	pleckstrin; Major protein kinase C substrate of platelets	0.653
ACTN1	PLS1	ENSP00000377941	ENSP00000336831	actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	plastin 1; Actin-bundling protein in the absence of calcium	0.659
ACTN1	TRIOBP	ENSP00000377941	ENSP00000384312	actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	TRIO and F-actin binding protein	0.511
ACTN1	UBC	ENSP00000377941	ENSP00000344818	actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	ubiquitin C	0.931
DBR1	TRIOBP	ENSP00000260803	ENSP00000384312	debranching enzyme homolog 1 (S. cerevisiae); Cleaves the 2’-5’ phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis	TRIO and F-actin binding protein	0.528
DBR1	UBC	ENSP00000260803	ENSP00000344818	debranching enzyme homolog 1 (S. cerevisiae); Cleaves the 2’-5’ phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis	ubiquitin C	0.639
DFNB59	TRIOBP	ENSP00000364271	ENSP00000384312	deafness, autosomal recessive 59; Essential in the activity of auditory pathway neurons	TRIO and F-actin binding protein	0.471
ESPN	PLS1	ENSP00000367059	ENSP00000336831	espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity)	plastin 1; Actin-bundling protein in the absence of calcium	0.505
ESPN	TRIOBP	ENSP00000367059	ENSP00000384312	espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity)	TRIO and F-actin binding protein	0.476
HECTD3	TRIOBP	ENSP00000361245	ENSP00000384312	HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity)	TRIO and F-actin binding protein	0.576
HECTD3	UBC	ENSP00000361245	ENSP00000344818	HECT domain containing E3 ubiquitin protein ligase 3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity)	ubiquitin C	0.782
PLEK	ACTN1	ENSP00000234313	ENSP00000377941	pleckstrin; Major protein kinase C substrate of platelets	actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	0.653
PLEK	TRIOBP	ENSP00000234313	ENSP00000384312	pleckstrin; Major protein kinase C substrate of platelets	TRIO and F-actin binding protein	0.560
PLEK	UBC	ENSP00000234313	ENSP00000344818	pleckstrin; Major protein kinase C substrate of platelets	ubiquitin C	0.522
PLK1	TERF1	ENSP00000300093	ENSP00000276603	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	telomeric repeat binding factor (NIMA-interacting) 1; Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair [...]	0.836
PLK1	TRIOBP	ENSP00000300093	ENSP00000384312	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	TRIO and F-actin binding protein	0.576
PLK1	UBC	ENSP00000300093	ENSP00000344818	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	ubiquitin C	0.998
PLS1	ACTN1	ENSP00000336831	ENSP00000377941	plastin 1; Actin-bundling protein in the absence of calcium	actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	0.659
PLS1	ESPN	ENSP00000336831	ENSP00000367059	plastin 1; Actin-bundling protein in the absence of calcium	espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells (By similarity)	0.505
PLS1	TRIOBP	ENSP00000336831	ENSP00000384312	plastin 1; Actin-bundling protein in the absence of calcium	TRIO and F-actin binding protein	0.507

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