MYH8 protein (Homo sapiens) - STRING network view

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MYH8

myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction (1937 aa)

Predicted Functional Partners:

TNNT3

0.978

TNNI2

0.977

TNNI1

0.973

TPM2

0.971

TNNC2

0.971

TNNI3

0.968

ACTN2

0.966

TPM1

0.965

TPM3

0.964

TNNT2

0.960

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	MYH8	ENSP00000355537	ENSP00000384330	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	0.966
ACTN2	TNNC2	ENSP00000355537	ENSP00000361636	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments	0.939
ACTN2	TNNI1	ENSP00000355537	ENSP00000337022	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	troponin I type 1 (skeletal, slow)	0.942
ACTN2	TNNI2	ENSP00000355537	ENSP00000252898	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.939
ACTN2	TNNI3	ENSP00000355537	ENSP00000341838	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.936
ACTN2	TNNT2	ENSP00000355537	ENSP00000356286	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.957
ACTN2	TNNT3	ENSP00000355537	ENSP00000278317	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	troponin T type 3 (skeletal, fast)	0.977
ACTN2	TPM1	ENSP00000355537	ENSP00000267996	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	tropomyosin 1 (alpha)	0.973
ACTN2	TPM2	ENSP00000355537	ENSP00000354219	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity)	0.967
ACTN2	TPM3	ENSP00000355537	ENSP00000357516	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments	0.971
MYH8	ACTN2	ENSP00000384330	ENSP00000355537	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein	0.966
MYH8	TNNC2	ENSP00000384330	ENSP00000361636	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments	0.971
MYH8	TNNI1	ENSP00000384330	ENSP00000337022	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	troponin I type 1 (skeletal, slow)	0.973
MYH8	TNNI2	ENSP00000384330	ENSP00000252898	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.977
MYH8	TNNI3	ENSP00000384330	ENSP00000341838	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.968
MYH8	TNNT2	ENSP00000384330	ENSP00000356286	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.960
MYH8	TNNT3	ENSP00000384330	ENSP00000278317	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	troponin T type 3 (skeletal, fast)	0.978
MYH8	TPM1	ENSP00000384330	ENSP00000267996	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	tropomyosin 1 (alpha)	0.965
MYH8	TPM2	ENSP00000384330	ENSP00000354219	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity)	0.971
MYH8	TPM3	ENSP00000384330	ENSP00000357516	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments	0.964

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