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STRINGSTRING
CAPN10 CAPN10 GRP GRP GNAI1 GNAI1 TPST2 TPST2 TPST1 TPST1 GPR1 GPR1 GPR75 GPR75 GPR37 GPR37 GPR22 GPR22 GPR21 GPR21 RARRES2 RARRES2
"GPR1" - G protein-coupled receptor 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
GPR1G protein-coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1 (355 aa)    
Predicted Functional Partners:
GPR22
G protein-coupled receptor 22; Orphan receptor (433 aa)
            score_image   0.751
GPR21
G protein-coupled receptor 21; Orphan receptor (349 aa)
            score_image   0.748
GPR75
G protein-coupled receptor 75; Orphan receptor (540 aa)
            score_image   0.650
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (354 aa)
        score_image   score_image   0.585
TPST2
tyrosylprotein sulfotransferase 2; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (377 aa)
        score_image       0.573
TPST1
tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (370 aa)
        score_image       0.573
RARRES2
retinoic acid receptor responder (tazarotene induced) 2 (163 aa)
            score_image   0.555
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system (613 aa)
            score_image   0.547
CAPN10
calpain 10 (672 aa)
            score_image   0.516
GRP
gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) (148 aa)
            score_image   0.513
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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