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STRINGSTRING
SSR2 SSR2 SEC61A2 SEC61A2 SNRPB SNRPB SEC61A1 SEC61A1 SNRPN SNRPN TDRD15 TDRD15 AIFM3 AIFM3 STK31 STK31 PIWIL4 PIWIL4 PIWIL1 PIWIL1
"TDRD15" - Uncharacterized protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TDRD15Uncharacterized protein (1934 aa)    
Predicted Functional Partners:
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) (476 aa)
      score_image         0.707
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae) (476 aa)
      score_image         0.707
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner (By similarity) (240 aa)
            score_image   0.592
SNRPN
small nuclear ribonucleoprotein polypeptide N; May be involved in tissue-specific alternative RNA processing events (240 aa)
            score_image   0.592
STK31
serine/threonine kinase 31 (1019 aa)
            score_image   0.551
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (605 aa)
            score_image   0.543
PIWIL4
piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] (852 aa)
        score_image   score_image   0.429
PIWIL1
piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] (861 aa)
        score_image   score_image   0.429
SSR2
signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins (183 aa)
      score_image         0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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