node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIFM3 | TDRD15 | ENSP00000382120 | ENSP00000384376 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Uncharacterized protein | 0.543 |
PIWIL1 | STK31 | ENSP00000245255 | ENSP00000348132 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | serine/threonine kinase 31 | 0.472 |
PIWIL1 | TDRD15 | ENSP00000245255 | ENSP00000384376 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | Uncharacterized protein | 0.429 |
PIWIL4 | STK31 | ENSP00000299001 | ENSP00000348132 | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | serine/threonine kinase 31 | 0.457 |
PIWIL4 | TDRD15 | ENSP00000299001 | ENSP00000384376 | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | Uncharacterized protein | 0.429 |
SEC61A1 | SEC61A2 | ENSP00000243253 | ENSP00000298428 | Sec61 alpha 1 subunit (S. cerevisiae) | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) | 0.900 |
SEC61A1 | SSR2 | ENSP00000243253 | ENSP00000295702 | Sec61 alpha 1 subunit (S. cerevisiae) | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | 0.900 |
SEC61A1 | TDRD15 | ENSP00000243253 | ENSP00000384376 | Sec61 alpha 1 subunit (S. cerevisiae) | Uncharacterized protein | 0.707 |
SEC61A2 | SEC61A1 | ENSP00000298428 | ENSP00000243253 | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) | Sec61 alpha 1 subunit (S. cerevisiae) | 0.900 |
SEC61A2 | SSR2 | ENSP00000298428 | ENSP00000295702 | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | 0.802 |
SEC61A2 | TDRD15 | ENSP00000298428 | ENSP00000384376 | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) | Uncharacterized protein | 0.707 |
SNRPB | TDRD15 | ENSP00000412566 | ENSP00000384376 | small nuclear ribonucleoprotein polypeptides B and B1; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner (By similarity) | Uncharacterized protein | 0.592 |
SNRPN | TDRD15 | ENSP00000306223 | ENSP00000384376 | small nuclear ribonucleoprotein polypeptide N; May be involved in tissue-specific alternative RNA processing events | Uncharacterized protein | 0.592 |
SSR2 | SEC61A1 | ENSP00000295702 | ENSP00000243253 | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | Sec61 alpha 1 subunit (S. cerevisiae) | 0.900 |
SSR2 | SEC61A2 | ENSP00000295702 | ENSP00000298428 | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) | 0.802 |
SSR2 | TDRD15 | ENSP00000295702 | ENSP00000384376 | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | Uncharacterized protein | 0.426 |
STK31 | PIWIL1 | ENSP00000348132 | ENSP00000245255 | serine/threonine kinase 31 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.472 |
STK31 | PIWIL4 | ENSP00000348132 | ENSP00000299001 | serine/threonine kinase 31 | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.457 |
STK31 | TDRD15 | ENSP00000348132 | ENSP00000384376 | serine/threonine kinase 31 | Uncharacterized protein | 0.551 |
TDRD15 | AIFM3 | ENSP00000384376 | ENSP00000382120 | Uncharacterized protein | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.543 |