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TAC4 TAC4 TOP2A TOP2A PGS1 PGS1 TOP2B TOP2B CHKB CHKB CEPT1 CEPT1 PCYT1B PCYT1B PISD PISD CHPT1 CHPT1 CPT1B CPT1B CPT1C CPT1C
"CHKB" - choline kinase beta in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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Score
CHKBcholine kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (395 aa)    
Predicted Functional Partners:
CPT1B
carnitine palmitoyltransferase 1B (muscle) (772 aa)
      score_image     score_image   0.874
TAC4
tachykinin 4 (hemokinin); Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility (113 aa)
            score_image   0.863
CPT1C
carnitine palmitoyltransferase 1C (803 aa)
            score_image   0.860
CHPT1
choline phosphotransferase 1 (406 aa)
            score_image   0.617
PISD
phosphatidylserine decarboxylase (375 aa)
      score_image     score_image   0.608
PCYT1B
phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis (369 aa)
      score_image     score_image   0.598
CEPT1
choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (416 aa)
            score_image   0.577
TOP2A
topoisomerase (DNA) II alpha 170kDa (1531 aa)
            score_image   0.568
TOP2B
topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (1621 aa)
            score_image   0.568
PGS1
phosphatidylglycerophosphate synthase 1; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin (By similarity) (556 aa)
        score_image   score_image   0.521
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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