node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEPT1 | CHKB | ENSP00000349696 | ENSP00000384400 | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | 0.577 |
CEPT1 | CHPT1 | ENSP00000349696 | ENSP00000229266 | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | choline phosphotransferase 1 | 0.901 |
CEPT1 | PCYT1B | ENSP00000349696 | ENSP00000368439 | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis | 0.990 |
CEPT1 | PGS1 | ENSP00000349696 | ENSP00000262764 | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | phosphatidylglycerophosphate synthase 1; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin (By similarity) | 0.502 |
CEPT1 | PISD | ENSP00000349696 | ENSP00000266095 | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | phosphatidylserine decarboxylase | 0.971 |
CHKB | CEPT1 | ENSP00000384400 | ENSP00000349696 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | 0.577 |
CHKB | CHPT1 | ENSP00000384400 | ENSP00000229266 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | choline phosphotransferase 1 | 0.617 |
CHKB | CPT1B | ENSP00000384400 | ENSP00000312189 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | carnitine palmitoyltransferase 1B (muscle) | 0.874 |
CHKB | CPT1C | ENSP00000384400 | ENSP00000319343 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | carnitine palmitoyltransferase 1C | 0.860 |
CHKB | PCYT1B | ENSP00000384400 | ENSP00000368439 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis | 0.598 |
CHKB | PGS1 | ENSP00000384400 | ENSP00000262764 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | phosphatidylglycerophosphate synthase 1; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin (By similarity) | 0.521 |
CHKB | PISD | ENSP00000384400 | ENSP00000266095 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | phosphatidylserine decarboxylase | 0.608 |
CHKB | TAC4 | ENSP00000384400 | ENSP00000334042 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | tachykinin 4 (hemokinin); Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility | 0.863 |
CHKB | TOP2A | ENSP00000384400 | ENSP00000411532 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | topoisomerase (DNA) II alpha 170kDa | 0.568 |
CHKB | TOP2B | ENSP00000384400 | ENSP00000396704 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.568 |
CHPT1 | CEPT1 | ENSP00000229266 | ENSP00000349696 | choline phosphotransferase 1 | choline/ethanolamine phosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity | 0.901 |
CHPT1 | CHKB | ENSP00000229266 | ENSP00000384400 | choline phosphotransferase 1 | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | 0.617 |
CHPT1 | PCYT1B | ENSP00000229266 | ENSP00000368439 | choline phosphotransferase 1 | phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis | 0.986 |
CHPT1 | PISD | ENSP00000229266 | ENSP00000266095 | choline phosphotransferase 1 | phosphatidylserine decarboxylase | 0.611 |
CPT1B | CHKB | ENSP00000312189 | ENSP00000384400 | carnitine palmitoyltransferase 1B (muscle) | choline kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis | 0.874 |