| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCL1 | ICOSLG | ENSP00000225842 | ENSP00000384432 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | 0.700 |
| CCL1 | KLK15 | ENSP00000225842 | ENSP00000469315 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | kallikrein-related peptidase 15; Protease whose physiological substrate is not yet known | 0.581 |
| CCL1 | PHB2 | ENSP00000225842 | ENSP00000441875 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.812 |
| CCL1 | SPTAN1 | ENSP00000225842 | ENSP00000361824 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | spectrin, alpha, non-erythrocytic 1 | 0.816 |
| CD28 | CTLA4 | ENSP00000324890 | ENSP00000303939 | CD28 molecule | cytotoxic T-lymphocyte-associated protein 4 | 0.918 |
| CD28 | ICOSLG | ENSP00000324890 | ENSP00000384432 | CD28 molecule | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | 0.811 |
| CTLA4 | CD28 | ENSP00000303939 | ENSP00000324890 | cytotoxic T-lymphocyte-associated protein 4 | CD28 molecule | 0.918 |
| CTLA4 | ICOS | ENSP00000303939 | ENSP00000319476 | cytotoxic T-lymphocyte-associated protein 4 | inducible T-cell co-stimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching [...] | 0.800 |
| CTLA4 | ICOSLG | ENSP00000303939 | ENSP00000384432 | cytotoxic T-lymphocyte-associated protein 4 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | 0.985 |
| CXCL12 | ICOSLG | ENSP00000379140 | ENSP00000384432 | chemokine (C-X-C motif) ligand 12 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | 0.800 |
| EDA | ICOSLG | ENSP00000363680 | ENSP00000384432 | ectodysplasin A | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | 0.658 |
| EDA | KLK15 | ENSP00000363680 | ENSP00000469315 | ectodysplasin A | kallikrein-related peptidase 15; Protease whose physiological substrate is not yet known | 0.648 |
| EDA | NUMA1 | ENSP00000363680 | ENSP00000377298 | ectodysplasin A | nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions | 0.824 |
| EDA | PHB2 | ENSP00000363680 | ENSP00000441875 | ectodysplasin A | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.814 |
| EDA | SPTAN1 | ENSP00000363680 | ENSP00000361824 | ectodysplasin A | spectrin, alpha, non-erythrocytic 1 | 0.636 |
| ICOS | CTLA4 | ENSP00000319476 | ENSP00000303939 | inducible T-cell co-stimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching [...] | cytotoxic T-lymphocyte-associated protein 4 | 0.800 |
| ICOS | ICOSLG | ENSP00000319476 | ENSP00000384432 | inducible T-cell co-stimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching [...] | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | 0.992 |
| ICOSLG | CCL1 | ENSP00000384432 | ENSP00000225842 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | 0.700 |
| ICOSLG | CD28 | ENSP00000384432 | ENSP00000324890 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | CD28 molecule | 0.811 |
| ICOSLG | CTLA4 | ENSP00000384432 | ENSP00000303939 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | cytotoxic T-lymphocyte-associated protein 4 | 0.985 |
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