| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDH5 | CLDN5 | ENSP00000344115 | ENSP00000384554 | cadherin 5, type 2 (vascular endothelium); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These [...] | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.945 |
| CDH5 | ESAM | ENSP00000344115 | ENSP00000278927 | cadherin 5, type 2 (vascular endothelium); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These [...] | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.738 |
| CDH5 | OCLN | ENSP00000344115 | ENSP00000347379 | cadherin 5, type 2 (vascular endothelium); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These [...] | occludin | 0.703 |
| CDH5 | TJP1 | ENSP00000344115 | ENSP00000281537 | cadherin 5, type 2 (vascular endothelium); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These [...] | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.846 |
| CDH5 | TJP2 | ENSP00000344115 | ENSP00000438262 | cadherin 5, type 2 (vascular endothelium); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These [...] | tight junction protein 2 | 0.450 |
| CLDN1 | CLDN23 | ENSP00000295522 | ENSP00000428780 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | 0.826 |
| CLDN1 | CLDN5 | ENSP00000295522 | ENSP00000384554 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.914 |
| CLDN1 | ESAM | ENSP00000295522 | ENSP00000278927 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.800 |
| CLDN1 | INADL | ENSP00000295522 | ENSP00000360200 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | InaD-like (Drosophila) | 0.959 |
| CLDN1 | MPDZ | ENSP00000295522 | ENSP00000370410 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | multiple PDZ domain protein | 0.943 |
| CLDN1 | OCLN | ENSP00000295522 | ENSP00000347379 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | occludin | 0.725 |
| CLDN1 | TJP1 | ENSP00000295522 | ENSP00000281537 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.979 |
| CLDN1 | TJP2 | ENSP00000295522 | ENSP00000438262 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tight junction protein 2 | 0.977 |
| CLDN1 | TJP3 | ENSP00000295522 | ENSP00000262968 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | tight junction protein 3 | 0.976 |
| CLDN23 | CLDN1 | ENSP00000428780 | ENSP00000295522 | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.826 |
| CLDN23 | CLDN5 | ENSP00000428780 | ENSP00000384554 | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.865 |
| CLDN23 | ESAM | ENSP00000428780 | ENSP00000278927 | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.800 |
| CLDN23 | INADL | ENSP00000428780 | ENSP00000360200 | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | InaD-like (Drosophila) | 0.856 |
| CLDN23 | MPDZ | ENSP00000428780 | ENSP00000370410 | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | multiple PDZ domain protein | 0.847 |
| CLDN23 | TJP1 | ENSP00000428780 | ENSP00000281537 | claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.835 |
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