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DZIP3 DZIP3 DZIP1 DZIP1 DAZAP1 DAZAP1 DAZAP2 DAZAP2 DAZ1 DAZ1 DAZL DAZL PUM2 PUM2 USP9Y USP9Y BOLL BOLL CDY1B CDY1B CDY1 CDY1
"DAZ1" - deleted in azoospermia 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
DAZ1deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells (744 aa)    
Predicted Functional Partners:
DZIP1
DAZ interacting protein 1; May participate in spermatogenesis via its interaction with DAZ (867 aa)
        score_image   score_image   0.989
DAZAP2
DAZ associated protein 2 (207 aa)
        score_image   score_image   0.986
DAZL
deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) (315 aa)
        score_image   score_image score_image 0.920
PUM2
pumilio homolog 2 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (1064 aa)
        score_image   score_image   0.908
BOLL
bol, boule-like (Drosophila); Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity) (295 aa)
        score_image   score_image score_image 0.852
CDY1B
chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4 (554 aa)
            score_image   0.824
CDY1
chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4 (554 aa)
            score_image   0.824
USP9Y
ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...] (2555 aa)
            score_image   0.814
DZIP3
DAZ interacting protein 3, zinc finger (1208 aa)
        score_image   score_image   0.804
DAZAP1
DAZ associated protein 1; RNA-binding protein, which may be required during spermatogenesis (407 aa)
        score_image   score_image score_image 0.771
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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