splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM59B
family with sequence similarity 59, member B; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway (By similarity) (874 aa)
Predicted Functional Partners:
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (217 aa)
0.517
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
FAM59B
GRB2
ENSP00000384593
ENSP00000339007
family with sequence similarity 59, member B; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway (By similarity)
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway
0.517
GRB2
FAM59B
ENSP00000339007
ENSP00000384593
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway
family with sequence similarity 59, member B; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway (By similarity)
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: