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TRIP6 TRIP6 SLC9A3R2 SLC9A3R2 LPAR4 LPAR4 LPAR2 LPAR2 LPAR6 LPAR6 GNA11 GNA11 RHOA RHOA GNAQ GNAQ LPAR5 LPAR5 GNAI1 GNAI1 GNAI3 GNAI3
"LPAR2" - lysophosphatidic acid receptor 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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LPAR2lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (351 aa)    
Predicted Functional Partners:
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (337 aa)
        score_image score_image score_image   0.997
TRIP6
thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (476 aa)
        score_image score_image score_image   0.997
LPAR4
lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA (370 aa)
          score_image score_image   0.986
LPAR6
lysophosphatidic acid receptor 6 (344 aa)
          score_image score_image   0.983
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (354 aa)
        score_image score_image score_image   0.960
LPAR5
lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities (372 aa)
          score_image score_image   0.956
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (354 aa)
        score_image score_image score_image   0.955
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) (359 aa)
        score_image score_image score_image   0.952
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (359 aa)
        score_image score_image score_image   0.952
RHOA
ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa)
          score_image score_image   0.949
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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