MMD2 protein (Homo sapiens) - STRING network view

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Score

MMD2

monocyte to macrophage differentiation-associated 2 (270 aa)

Predicted Functional Partners:

TLR4

0.904

ANO5

0.860

DYSF

0.758

LY96

0.611

BUD31

0.594

HDDC3

0.542

MYOC

0.497

DDX53

0.482

DDX43

0.482

TLR2

0.460

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO5	DYSF	ENSP00000315371	ENSP00000386881	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.902
ANO5	MMD2	ENSP00000315371	ENSP00000384690	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	monocyte to macrophage differentiation-associated 2	0.860
BUD31	MMD2	ENSP00000222969	ENSP00000384690	BUD31 homolog (S. cerevisiae)	monocyte to macrophage differentiation-associated 2	0.594
DDX43	MMD2	ENSP00000359361	ENSP00000384690	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	monocyte to macrophage differentiation-associated 2	0.482
DDX53	MMD2	ENSP00000368667	ENSP00000384690	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	monocyte to macrophage differentiation-associated 2	0.482
DYSF	ANO5	ENSP00000386881	ENSP00000315371	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	0.902
DYSF	MMD2	ENSP00000386881	ENSP00000384690	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	monocyte to macrophage differentiation-associated 2	0.758
HDDC3	MMD2	ENSP00000330721	ENSP00000384690	HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response	monocyte to macrophage differentiation-associated 2	0.542
LY96	MMD2	ENSP00000284818	ENSP00000384690	lymphocyte antigen 96; Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS	monocyte to macrophage differentiation-associated 2	0.611
LY96	TLR2	ENSP00000284818	ENSP00000260010	lymphocyte antigen 96; Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS	toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface [...]	0.983
LY96	TLR4	ENSP00000284818	ENSP00000363089	lymphocyte antigen 96; Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS	toll-like receptor 4	0.999
MMD2	ANO5	ENSP00000384690	ENSP00000315371	monocyte to macrophage differentiation-associated 2	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	0.860
MMD2	BUD31	ENSP00000384690	ENSP00000222969	monocyte to macrophage differentiation-associated 2	BUD31 homolog (S. cerevisiae)	0.594
MMD2	DDX43	ENSP00000384690	ENSP00000359361	monocyte to macrophage differentiation-associated 2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	0.482
MMD2	DDX53	ENSP00000384690	ENSP00000368667	monocyte to macrophage differentiation-associated 2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	0.482
MMD2	DYSF	ENSP00000384690	ENSP00000386881	monocyte to macrophage differentiation-associated 2	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.758
MMD2	HDDC3	ENSP00000384690	ENSP00000330721	monocyte to macrophage differentiation-associated 2	HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response	0.542
MMD2	LY96	ENSP00000384690	ENSP00000284818	monocyte to macrophage differentiation-associated 2	lymphocyte antigen 96; Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS	0.611
MMD2	MYOC	ENSP00000384690	ENSP00000037502	monocyte to macrophage differentiation-associated 2	myocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork	0.497
MMD2	TLR2	ENSP00000384690	ENSP00000260010	monocyte to macrophage differentiation-associated 2	toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface [...]	0.460

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