node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRB2 | FSHR | ENSP00000305372 | ENSP00000384708 | adrenoceptor beta 2, surface | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.925 |
ADRB2 | GNAS | ENSP00000305372 | ENSP00000360141 | adrenoceptor beta 2, surface | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.972 |
ADRB2 | MC2R | ENSP00000305372 | ENSP00000333821 | adrenoceptor beta 2, surface | melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase | 0.901 |
ADRB2 | POMC | ENSP00000305372 | ENSP00000264708 | adrenoceptor beta 2, surface | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.917 |
ADRB2 | VIP | ENSP00000305372 | ENSP00000356213 | adrenoceptor beta 2, surface | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.901 |
CGA | FSHB | ENSP00000358595 | ENSP00000254122 | glycoprotein hormones, alpha polypeptide | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | 0.999 |
CGA | FSHR | ENSP00000358595 | ENSP00000384708 | glycoprotein hormones, alpha polypeptide | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.994 |
CGA | POMC | ENSP00000358595 | ENSP00000264708 | glycoprotein hormones, alpha polypeptide | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.936 |
FOXO1 | FSHR | ENSP00000368880 | ENSP00000384708 | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.937 |
FOXO1 | POMC | ENSP00000368880 | ENSP00000264708 | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.872 |
FOXO1 | YWHAQ | ENSP00000368880 | ENSP00000238081 | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 | 0.914 |
FSHB | CGA | ENSP00000254122 | ENSP00000358595 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | glycoprotein hormones, alpha polypeptide | 0.999 |
FSHB | FSHR | ENSP00000254122 | ENSP00000384708 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | 0.999 |
FSHB | GNAS | ENSP00000254122 | ENSP00000360141 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.900 |
FSHR | ADRB2 | ENSP00000384708 | ENSP00000305372 | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | adrenoceptor beta 2, surface | 0.925 |
FSHR | CGA | ENSP00000384708 | ENSP00000358595 | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | glycoprotein hormones, alpha polypeptide | 0.994 |
FSHR | FOXO1 | ENSP00000384708 | ENSP00000368880 | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | 0.937 |
FSHR | FSHB | ENSP00000384708 | ENSP00000254122 | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | 0.999 |
FSHR | GDF9 | ENSP00000384708 | ENSP00000296875 | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | growth differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells | 0.942 |
FSHR | GNAS | ENSP00000384708 | ENSP00000360141 | follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.922 |