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STRINGSTRING
NUBPL NUBPL PPP1R9A PPP1R9A SVOPL SVOPL SLC22A23 SLC22A23 TTC19 TTC19 SPNS3 SPNS3 PRPF4B PRPF4B BDH2 BDH2
"SLC22A23" - solute carrier family 22, member 23 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
SLC22A23solute carrier family 22, member 23 (686 aa)    
Predicted Functional Partners:
SPNS3
spinster homolog 3 (Drosophila); Sphingolipid transporter (By similarity) (512 aa)
            score_image   0.691
PRPF4B
PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (1007 aa)
            score_image   0.626
NUBPL
nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (319 aa)
            score_image   0.575
SVOPL
SVOP-like (492 aa)
            score_image   0.539
BDH2
3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) (245 aa)
            score_image   0.459
PPP1R9A
protein phosphatase 1, regulatory subunit 9A; Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha activity (By similarity) (1374 aa)
            score_image   0.432
TTC19
tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence (501 aa)
            score_image   0.412
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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