| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADIPOQ | CD40LG | ENSP00000320709 | ENSP00000359663 | adiponectin, C1Q and collagen domain containing; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play [...] | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | 0.653 |
| ADIPOQ | TNFSF18 | ENSP00000320709 | ENSP00000385470 | adiponectin, C1Q and collagen domain containing; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play [...] | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.584 |
| CD40LG | ADIPOQ | ENSP00000359663 | ENSP00000320709 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | adiponectin, C1Q and collagen domain containing; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play [...] | 0.653 |
| CD40LG | TNFRSF4 | ENSP00000359663 | ENSP00000368538 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.598 |
| CD40LG | TNFSF18 | ENSP00000359663 | ENSP00000385470 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.643 |
| CD40LG | TNFSF4 | ENSP00000359663 | ENSP00000281834 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production | 0.450 |
| CD40LG | TNFSF8 | ENSP00000359663 | ENSP00000223795 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells | 0.525 |
| CD40LG | TNFSF9 | ENSP00000359663 | ENSP00000245817 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages | 0.499 |
| ICOSLG | TNFSF18 | ENSP00000384432 | ENSP00000385470 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.487 |
| ICOSLG | TNFSF4 | ENSP00000384432 | ENSP00000281834 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production | 0.418 |
| ICOSLG | TNFSF9 | ENSP00000384432 | ENSP00000245817 | inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity) | tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages | 0.483 |
| LTBR | TNFSF18 | ENSP00000228918 | ENSP00000385470 | lymphotoxin beta receptor (TNFR superfamily, member 3); Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.487 |
| TNFRSF18 | TNFRSF4 | ENSP00000328207 | ENSP00000368538 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.660 |
| TNFRSF18 | TNFSF18 | ENSP00000328207 | ENSP00000385470 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.998 |
| TNFRSF18 | TNFSF4 | ENSP00000328207 | ENSP00000281834 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production | 0.418 |
| TNFRSF4 | CD40LG | ENSP00000368538 | ENSP00000359663 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | 0.598 |
| TNFRSF4 | TNFRSF18 | ENSP00000368538 | ENSP00000328207 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | tumor necrosis factor receptor superfamily, member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway | 0.660 |
| TNFRSF4 | TNFSF18 | ENSP00000368538 | ENSP00000385470 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B | 0.459 |
| TNFRSF4 | TNFSF4 | ENSP00000368538 | ENSP00000281834 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production | 0.999 |
| TNFRSF4 | TNFSF8 | ENSP00000368538 | ENSP00000223795 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells | 0.520 |
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