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STRINGSTRING
HIST1H4L HIST1H4L HIST1H4F HIST1H4F HIST1H4B HIST1H4B HIST2H4A HIST2H4A HIST2H4B HIST2H4B HIST2H3A HIST2H3A HIST1H4E HIST1H4E HIST1H4I HIST1H4I HIST1H4A HIST1H4A HIST4H4 HIST4H4 HIST1H4K HIST1H4K
"HIST2H3A" - histone cluster 2, H3a in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIST2H3Ahistone cluster 2, H3a (136 aa)    
Predicted Functional Partners:
HIST1H4L
histone cluster 1, H4l (103 aa)
      score_image score_image   score_image   0.849
HIST2H4B
histone cluster 2, H4b (103 aa)
      score_image score_image   score_image   0.849
HIST1H4E
histone cluster 1, H4e (103 aa)
      score_image score_image   score_image   0.849
HIST1H4K
histone cluster 1, H4k (103 aa)
      score_image score_image   score_image   0.849
HIST4H4
histone cluster 4, H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (103 aa)
      score_image score_image   score_image   0.849
HIST1H4I
histone cluster 1, H4i (103 aa)
      score_image score_image   score_image   0.849
HIST1H4F
histone cluster 1, H4f (103 aa)
      score_image score_image   score_image   0.846
HIST1H4B
histone cluster 1, H4b (103 aa)
      score_image score_image   score_image   0.846
HIST2H4A
histone cluster 2, H4a (103 aa)
      score_image score_image   score_image   0.846
HIST1H4A
histone cluster 1, H4a (103 aa)
      score_image score_image   score_image   0.846
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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