node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACAT1 | ENSP00000333664 | ENSP00000265838 | acetyl-CoA acyltransferase 1 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.924 |
ACAA1 | ACAT2 | ENSP00000333664 | ENSP00000356015 | acetyl-CoA acyltransferase 1 | acetyl-CoA acetyltransferase 2 | 0.911 |
ACAA1 | ECHS1 | ENSP00000333664 | ENSP00000357535 | acetyl-CoA acyltransferase 1 | enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate | 0.867 |
ACAA1 | EHHADH | ENSP00000333664 | ENSP00000231887 | acetyl-CoA acyltransferase 1 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.998 |
ACAA1 | HADH | ENSP00000333664 | ENSP00000385638 | acetyl-CoA acyltransferase 1 | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA | 0.984 |
ACAA1 | HADHA | ENSP00000333664 | ENSP00000370023 | acetyl-CoA acyltransferase 1 | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.999 |
ACAA1 | HIBCH | ENSP00000333664 | ENSP00000352706 | acetyl-CoA acyltransferase 1 | 3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | 0.747 |
ACAA1 | OXCT1 | ENSP00000333664 | ENSP00000196371 | acetyl-CoA acyltransferase 1 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.855 |
ACAA2 | ACAT1 | ENSP00000285093 | ENSP00000265838 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.972 |
ACAA2 | ACAT2 | ENSP00000285093 | ENSP00000356015 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 2 | 0.908 |
ACAA2 | ECHS1 | ENSP00000285093 | ENSP00000357535 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate | 0.899 |
ACAA2 | EHHADH | ENSP00000285093 | ENSP00000231887 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.998 |
ACAA2 | HADH | ENSP00000285093 | ENSP00000385638 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA | 0.987 |
ACAA2 | HADHA | ENSP00000285093 | ENSP00000370023 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit | 0.999 |
ACAA2 | HIBCH | ENSP00000285093 | ENSP00000352706 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | 0.780 |
ACAA2 | OXCT1 | ENSP00000285093 | ENSP00000196371 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.859 |
ACAT1 | ACAA1 | ENSP00000265838 | ENSP00000333664 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 1 | 0.924 |
ACAT1 | ACAA2 | ENSP00000265838 | ENSP00000285093 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.972 |
ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acetyltransferase 2 | 0.841 |
ACAT1 | ECHS1 | ENSP00000265838 | ENSP00000357535 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate | 0.908 |