HADH protein (Homo sapiens) - STRING network view

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HADH

hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA (331 aa)

Predicted Functional Partners:

ECHS1

0.997

HADHB

0.993

ACAA2

0.987

ACAA1

0.984

ACAT1

0.984

ACAT2

0.981

HIBCH

0.965

EHHADH

0.962

OXCT1

0.961

HADHA

0.960

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.924
ACAA1	ACAT2	ENSP00000333664	ENSP00000356015	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 2	0.911
ACAA1	ECHS1	ENSP00000333664	ENSP00000357535	acetyl-CoA acyltransferase 1	enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate	0.867
ACAA1	EHHADH	ENSP00000333664	ENSP00000231887	acetyl-CoA acyltransferase 1	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.998
ACAA1	HADH	ENSP00000333664	ENSP00000385638	acetyl-CoA acyltransferase 1	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.984
ACAA1	HADHA	ENSP00000333664	ENSP00000370023	acetyl-CoA acyltransferase 1	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit	0.999
ACAA1	HIBCH	ENSP00000333664	ENSP00000352706	acetyl-CoA acyltransferase 1	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	0.747
ACAA1	OXCT1	ENSP00000333664	ENSP00000196371	acetyl-CoA acyltransferase 1	3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.855
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.972
ACAA2	ACAT2	ENSP00000285093	ENSP00000356015	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 2	0.908
ACAA2	ECHS1	ENSP00000285093	ENSP00000357535	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate	0.899
ACAA2	EHHADH	ENSP00000285093	ENSP00000231887	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.998
ACAA2	HADH	ENSP00000285093	ENSP00000385638	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.987
ACAA2	HADHA	ENSP00000285093	ENSP00000370023	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit	0.999
ACAA2	HIBCH	ENSP00000285093	ENSP00000352706	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	0.780
ACAA2	OXCT1	ENSP00000285093	ENSP00000196371	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.859
ACAT1	ACAA1	ENSP00000265838	ENSP00000333664	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acyltransferase 1	0.924
ACAT1	ACAA2	ENSP00000265838	ENSP00000285093	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.972
ACAT1	ACAT2	ENSP00000265838	ENSP00000356015	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acetyltransferase 2	0.841
ACAT1	ECHS1	ENSP00000265838	ENSP00000357535	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate	0.908

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