node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | PLEKHB2 | ENSP00000448165 | ENSP00000385892 | apoptotic peptidase activating factor 1 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | 0.454 |
CDA | PLEKHB2 | ENSP00000364212 | ENSP00000385892 | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | 0.422 |
DAZAP2 | EPN1 | ENSP00000448051 | ENSP00000406209 | DAZ associated protein 2 | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | 0.526 |
DAZAP2 | PLEKHB2 | ENSP00000448051 | ENSP00000385892 | DAZ associated protein 2 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | 0.542 |
EPN1 | DAZAP2 | ENSP00000406209 | ENSP00000448051 | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | DAZ associated protein 2 | 0.526 |
EPN1 | PLEKHB2 | ENSP00000406209 | ENSP00000385892 | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | 0.790 |
FAM123C | PLEKHB2 | ENSP00000314914 | ENSP00000385892 | family with sequence similarity 123C; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | 0.418 |
PLEKHB2 | APAF1 | ENSP00000385892 | ENSP00000448165 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | apoptotic peptidase activating factor 1 | 0.454 |
PLEKHB2 | CDA | ENSP00000385892 | ENSP00000364212 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.422 |
PLEKHB2 | DAZAP2 | ENSP00000385892 | ENSP00000448051 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | DAZ associated protein 2 | 0.542 |
PLEKHB2 | EPN1 | ENSP00000385892 | ENSP00000406209 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | 0.790 |
PLEKHB2 | FAM123C | ENSP00000385892 | ENSP00000314914 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | family with sequence similarity 123C; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | 0.418 |
PLEKHB2 | SOCS1 | ENSP00000385892 | ENSP00000329418 | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | 0.811 |
SOCS1 | PLEKHB2 | ENSP00000329418 | ENSP00000385892 | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | pleckstrin homology domain containing, family B (evectins) member 2; Involved in retrograde transport of recycling endosomes | 0.811 |