Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
CGA CGA EYS EYS ANKFN1 ANKFN1 GABBR1 GABBR1 GABRR1 GABRR1 GABRR2 GABRR2 RRAGD RRAGD GABBR2 GABBR2 GABRA1 GABRA1 PM20D2 PM20D2 GABRR3 GABRR3
"GABRR2" - gamma-aminobutyric acid in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GABRR2gamma-aminobutyric acid (GABA) A receptor, rho 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (490 aa)    
Predicted Functional Partners:
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission (479 aa)
        score_image score_image score_image score_image 0.956
GABRR3
gamma-aminobutyric acid (GABA) A receptor, rho 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (By similarity) (467 aa)
          score_image score_image score_image 0.902
CGA
glycoprotein hormones, alpha polypeptide (116 aa)
            score_image   0.759
EYS
eyes shut homolog (Drosophila) (3144 aa)
            score_image   0.748
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2; Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a promi [...] (941 aa)
            score_image   0.678
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1 (763 aa)
            score_image   0.648
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1 (961 aa)
            score_image   0.632
PM20D2
peptidase M20 domain containing 2 (436 aa)
            score_image   0.628
RRAGD
Ras-related GTP binding D; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (400 aa)
            score_image   0.609
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (456 aa)
          score_image score_image score_image 0.600
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (45%)