node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf118 | GUCD1 | ENSP00000230301 | ENSP00000386076 | chromosome 6 open reading frame 118 | guanylyl cyclase domain containing 1 | 0.407 |
C6orf118 | SUGT1P3 | ENSP00000230301 | ENSP00000434236 | chromosome 6 open reading frame 118 | suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3 | 0.728 |
CTH | GUCD1 | ENSP00000359976 | ENSP00000386076 | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | guanylyl cyclase domain containing 1 | 0.499 |
CTH | UBC | ENSP00000359976 | ENSP00000344818 | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | ubiquitin C | 0.845 |
GUCD1 | C6orf118 | ENSP00000386076 | ENSP00000230301 | guanylyl cyclase domain containing 1 | chromosome 6 open reading frame 118 | 0.407 |
GUCD1 | CTH | ENSP00000386076 | ENSP00000359976 | guanylyl cyclase domain containing 1 | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | 0.499 |
GUCD1 | MME | ENSP00000386076 | ENSP00000353679 | guanylyl cyclase domain containing 1 | membrane metallo-endopeptidase; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers | 0.450 |
GUCD1 | NEDD4 | ENSP00000386076 | ENSP00000345530 | guanylyl cyclase domain containing 1 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.581 |
GUCD1 | RILPL1 | ENSP00000386076 | ENSP00000366070 | guanylyl cyclase domain containing 1 | Rab interacting lysosomal protein-like 1; Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution | 0.485 |
GUCD1 | SUGT1P3 | ENSP00000386076 | ENSP00000434236 | guanylyl cyclase domain containing 1 | suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3 | 0.499 |
GUCD1 | UBC | ENSP00000386076 | ENSP00000344818 | guanylyl cyclase domain containing 1 | ubiquitin C | 0.688 |
MME | GUCD1 | ENSP00000353679 | ENSP00000386076 | membrane metallo-endopeptidase; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers | guanylyl cyclase domain containing 1 | 0.450 |
NEDD4 | GUCD1 | ENSP00000345530 | ENSP00000386076 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | guanylyl cyclase domain containing 1 | 0.581 |
NEDD4 | UBC | ENSP00000345530 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
RILPL1 | GUCD1 | ENSP00000366070 | ENSP00000386076 | Rab interacting lysosomal protein-like 1; Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution | guanylyl cyclase domain containing 1 | 0.485 |
SUGT1P3 | C6orf118 | ENSP00000434236 | ENSP00000230301 | suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3 | chromosome 6 open reading frame 118 | 0.728 |
SUGT1P3 | GUCD1 | ENSP00000434236 | ENSP00000386076 | suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3 | guanylyl cyclase domain containing 1 | 0.499 |
UBC | CTH | ENSP00000344818 | ENSP00000359976 | ubiquitin C | cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] | 0.845 |
UBC | GUCD1 | ENSP00000344818 | ENSP00000386076 | ubiquitin C | guanylyl cyclase domain containing 1 | 0.688 |
UBC | NEDD4 | ENSP00000344818 | ENSP00000345530 | ubiquitin C | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.999 |