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STRINGSTRING
SPI-B SPI-B POLD2 POLD2 POLD1 POLD1 RFC4 RFC4 PCNA PCNA POLA1 POLA1 POLA2 POLA2 FEN1 FEN1 PRIM1 PRIM1 POLD3 POLD3 POLD4 POLD4
"POLD2" - polymerase (DNA directed), delta 2, accessory subunit in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Predicted Interactions
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protein homology
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POLD2polymerase (DNA directed), delta 2, accessory subunit; The function of the small subunit is not yet clear (469 aa)    
Predicted Functional Partners:
PCNA
proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] (261 aa)
      score_image score_image score_image score_image   0.999
POLD3
polymerase (DNA-directed), delta 3, accessory subunit; Required for optimal DNA polymerase delta activity (466 aa)
        score_image score_image score_image   0.999
POLD1
polymerase (DNA directed), delta 1, catalytic subunit; Possesses two enzymatic activities- DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3’- to 5’-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (1107 aa)
      score_image score_image score_image score_image   0.999
POLD4
polymerase (DNA-directed), delta 4, accessory subunit; Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta (107 aa)
        score_image score_image score_image   0.995
SPI-B
Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_a; Transcription factor Spi-B; cDNA FLJ57438, highly similar to Transcription factor Spi-B (397 aa)
      score_image score_image   score_image   0.986
POLA2
polymerase (DNA directed), alpha 2, accessory subunit; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity) (598 aa)
      score_image   score_image score_image   0.984
RFC4
replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (363 aa)
      score_image score_image score_image score_image   0.981
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by [...] (1462 aa)
      score_image score_image score_image score_image   0.972
FEN1
flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] (380 aa)
      score_image   score_image score_image   0.957
PRIM1
primase, DNA, polypeptide 1 (49kDa); DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication (420 aa)
      score_image   score_image score_image   0.950
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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