node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD1 | BTBD9 | ENSP00000339016 | ENSP00000386121 | ATPase family, AAA domain containing 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity) | BTB (POZ) domain containing 9 | 0.660 |
ATAD1 | UBC | ENSP00000339016 | ENSP00000344818 | ATPase family, AAA domain containing 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity) | ubiquitin C | 0.889 |
BTBD9 | ATAD1 | ENSP00000386121 | ENSP00000339016 | BTB (POZ) domain containing 9 | ATPase family, AAA domain containing 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity) | 0.660 |
BTBD9 | COPS6 | ENSP00000386121 | ENSP00000304102 | BTB (POZ) domain containing 9 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.640 |
BTBD9 | DGKE | ENSP00000386121 | ENSP00000284061 | BTB (POZ) domain containing 9 | diacylglycerol kinase, epsilon 64kDa; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition | 0.596 |
BTBD9 | MAP2K5 | ENSP00000386121 | ENSP00000178640 | BTB (POZ) domain containing 9 | mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis | 0.656 |
BTBD9 | MEIS1 | ENSP00000386121 | ENSP00000272369 | BTB (POZ) domain containing 9 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | 0.658 |
BTBD9 | PTPRD | ENSP00000386121 | ENSP00000348812 | BTB (POZ) domain containing 9 | protein tyrosine phosphatase, receptor type, D | 0.585 |
BTBD9 | SKOR1 | ENSP00000386121 | ENSP00000369374 | BTB (POZ) domain containing 9 | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling | 0.819 |
BTBD9 | UBC | ENSP00000386121 | ENSP00000344818 | BTB (POZ) domain containing 9 | ubiquitin C | 0.620 |
BTBD9 | USP21 | ENSP00000386121 | ENSP00000289865 | BTB (POZ) domain containing 9 | ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates | 0.756 |
BTBD9 | USP25 | ENSP00000386121 | ENSP00000285679 | BTB (POZ) domain containing 9 | ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains | 0.740 |
COPS6 | BTBD9 | ENSP00000304102 | ENSP00000386121 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | BTB (POZ) domain containing 9 | 0.640 |
COPS6 | UBC | ENSP00000304102 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | ubiquitin C | 0.973 |
DGKE | BTBD9 | ENSP00000284061 | ENSP00000386121 | diacylglycerol kinase, epsilon 64kDa; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition | BTB (POZ) domain containing 9 | 0.596 |
DGKE | UBC | ENSP00000284061 | ENSP00000344818 | diacylglycerol kinase, epsilon 64kDa; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition | ubiquitin C | 0.483 |
MAP2K5 | BTBD9 | ENSP00000178640 | ENSP00000386121 | mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis | BTB (POZ) domain containing 9 | 0.656 |
MAP2K5 | PTPRD | ENSP00000178640 | ENSP00000348812 | mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis | protein tyrosine phosphatase, receptor type, D | 0.547 |
MAP2K5 | SKOR1 | ENSP00000178640 | ENSP00000369374 | mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling | 0.748 |
MEIS1 | BTBD9 | ENSP00000272369 | ENSP00000386121 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | BTB (POZ) domain containing 9 | 0.658 |