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NFATC2 NFATC2 DISC1 DISC1 RPIA RPIA SP4 SP4 FOXP2 FOXP2 NKX2-1 NKX2-1 FOXP1 FOXP1 CTBP1 CTBP1 FOXP4 FOXP4 CDH2 CDH2 LEF1 LEF1
"FOXP2" - forkhead box P2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
FOXP2forkhead box P2 (740 aa)    
Predicted Functional Partners:
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (925 aa)
        score_image   score_image   0.912
CTBP1
C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity (440 aa)
        score_image   score_image   0.907
NKX2-1
NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis (401 aa)
            score_image   0.903
FOXP4
forkhead box P4; Transcriptional repressor that represses lung-specific expression (By similarity) (680 aa)
        score_image   score_image score_image 0.865
DISC1
disrupted in schizophrenia 1 (755 aa)
            score_image   0.832
FOXP1
forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) (677 aa)
        score_image   score_image score_image 0.816
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 [...] (399 aa)
        score_image   score_image   0.810
CDH2
cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) (906 aa)
            score_image   0.806
SP4
Sp4 transcription factor; Binds to GT and GC boxes promoters elements. Probable transcriptional activator (784 aa)
        score_image   score_image   0.789
RPIA
ribose 5-phosphate isomerase A (311 aa)
        score_image       0.753
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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