Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | HMSD | histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity) (139 aa) | ||||||||||||
Predicted Functional Partners:
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 | IL2RG | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins (369 aa) |
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0.680 | ||||||||||
 | CENPM | centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (180 aa) |
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0.568 | ||||||||||
 | P2RX5 | purinergic receptor P2X, ligand-gated ion channel, 5 (422 aa) |
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0.565 | ||||||||||
 | ENSG00000268107 | Uncharacterized protein (59 aa) |
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0.515 | ||||||||||
 | ZNF419 | zinc finger protein 419; May be involved in transcriptional regulation (511 aa) |
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0.511 | ||||||||||
 | XYLB | xylulokinase homolog (H. influenzae); Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis (536 aa) |
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0.509 | ||||||||||
 | ZNF773 | zinc finger protein 773; May be involved in transcriptional regulation (442 aa) |
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0.501 | ||||||||||
 | SERPINE3 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity) (424 aa) |
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0.495 | ||||||||||
 | SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (500 aa) |
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0.492 | ||||||||||
 | SERPINI2 | serpin peptidase inhibitor, clade I (pancpin), member 2 (405 aa) |
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0.492 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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