node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALAD | ALAS1 | ENSP00000386284 | ENSP00000309259 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | aminolevulinate, delta-, synthase 1 | 0.986 |
ALAD | ALAS2 | ENSP00000386284 | ENSP00000332369 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | aminolevulinate, delta-, synthase 2 | 0.979 |
ALAD | CPOX | ENSP00000386284 | ENSP00000264193 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III | 0.854 |
ALAD | FAH | ENSP00000386284 | ENSP00000261755 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 0.757 |
ALAD | FECH | ENSP00000386284 | ENSP00000372326 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | 0.906 |
ALAD | HMBS | ENSP00000386284 | ENSP00000278715 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | hydroxymethylbilane synthase | 0.989 |
ALAD | HPD | ENSP00000386284 | ENSP00000289004 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine | 0.753 |
ALAD | MGAM | ENSP00000386284 | ENSP00000447378 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | maltase-glucoamylase (alpha-glucosidase); May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing | 0.889 |
ALAD | UROD | ENSP00000386284 | ENSP00000246337 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.955 |
ALAD | UROS | ENSP00000386284 | ENSP00000357775 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) | 0.956 |
ALAS1 | ALAD | ENSP00000309259 | ENSP00000386284 | aminolevulinate, delta-, synthase 1 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | 0.986 |
ALAS1 | ALAS2 | ENSP00000309259 | ENSP00000332369 | aminolevulinate, delta-, synthase 1 | aminolevulinate, delta-, synthase 2 | 0.807 |
ALAS1 | CPOX | ENSP00000309259 | ENSP00000264193 | aminolevulinate, delta-, synthase 1 | coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III | 0.618 |
ALAS1 | FECH | ENSP00000309259 | ENSP00000372326 | aminolevulinate, delta-, synthase 1 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | 0.695 |
ALAS1 | HMBS | ENSP00000309259 | ENSP00000278715 | aminolevulinate, delta-, synthase 1 | hydroxymethylbilane synthase | 0.675 |
ALAS1 | UROD | ENSP00000309259 | ENSP00000246337 | aminolevulinate, delta-, synthase 1 | uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.683 |
ALAS1 | UROS | ENSP00000309259 | ENSP00000357775 | aminolevulinate, delta-, synthase 1 | uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) | 0.740 |
ALAS2 | ALAD | ENSP00000332369 | ENSP00000386284 | aminolevulinate, delta-, synthase 2 | aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen | 0.979 |
ALAS2 | ALAS1 | ENSP00000332369 | ENSP00000309259 | aminolevulinate, delta-, synthase 2 | aminolevulinate, delta-, synthase 1 | 0.807 |
ALAS2 | CPOX | ENSP00000332369 | ENSP00000264193 | aminolevulinate, delta-, synthase 2 | coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III | 0.632 |