SCN9A protein (Homo sapiens) - STRING network view

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SCN9A

sodium channel, voltage-gated, type IX, alpha subunit (1977 aa)

Predicted Functional Partners:

SCN1B

0.837

AGL

0.759

NAV1

0.757

MPV17

0.757

TBC1D24

0.755

GABRG2

0.749

ANKRD28

0.733

SCN2B

0.722

SCN4B

0.699

SCN3B

0.642

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGL	MPV17	ENSP00000294724	ENSP00000233545	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	0.818
AGL	SCN9A	ENSP00000294724	ENSP00000386306	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	sodium channel, voltage-gated, type IX, alpha subunit	0.759
ANKRD28	SCN9A	ENSP00000382379	ENSP00000386306	ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation	sodium channel, voltage-gated, type IX, alpha subunit	0.733
GABRG2	SCN1B	ENSP00000410732	ENSP00000396915	gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	0.749
GABRG2	SCN2B	ENSP00000410732	ENSP00000278947	gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)	0.428
GABRG2	SCN9A	ENSP00000410732	ENSP00000386306	gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	sodium channel, voltage-gated, type IX, alpha subunit	0.749
GABRG2	TBC1D24	ENSP00000410732	ENSP00000293970	gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function	0.636
MPV17	AGL	ENSP00000233545	ENSP00000294724	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.818
MPV17	SCN9A	ENSP00000233545	ENSP00000386306	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	sodium channel, voltage-gated, type IX, alpha subunit	0.757
NAV1	SCN2B	ENSP00000356265	ENSP00000278947	neuron navigator 1	sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)	0.655
NAV1	SCN4B	ENSP00000356265	ENSP00000322460	neuron navigator 1	sodium channel, voltage-gated, type IV, beta subunit; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity)	0.406
NAV1	SCN9A	ENSP00000356265	ENSP00000386306	neuron navigator 1	sodium channel, voltage-gated, type IX, alpha subunit	0.757
NAV1	TBC1D24	ENSP00000356265	ENSP00000293970	neuron navigator 1	TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function	0.471
SCN1B	GABRG2	ENSP00000396915	ENSP00000410732	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.749
SCN1B	SCN2B	ENSP00000396915	ENSP00000278947	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)	0.933
SCN1B	SCN3B	ENSP00000396915	ENSP00000299333	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	sodium channel, voltage-gated, type III, beta subunit; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity)	0.765
SCN1B	SCN4B	ENSP00000396915	ENSP00000322460	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	sodium channel, voltage-gated, type IV, beta subunit; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity)	0.926
SCN1B	SCN9A	ENSP00000396915	ENSP00000386306	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	sodium channel, voltage-gated, type IX, alpha subunit	0.837
SCN1B	TBC1D24	ENSP00000396915	ENSP00000293970	sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons	TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function	0.743
SCN2B	GABRG2	ENSP00000278947	ENSP00000410732	sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)	gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.428

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