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RAB38 RAB38 MYRIP MYRIP PCDH15 PCDH15 CDH23 CDH23 VEZT VEZT USH1C USH1C MYO7A MYO7A DFNB31 DFNB31 IQCB1 IQCB1 CALM1 CALM1 ACTA1 ACTA1
"MYO7A" - myosin VIIA in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
MYO7Amyosin VIIA; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphoge [...] (2215 aa)    
Predicted Functional Partners:
VEZT
vezatin, adherens junctions transmembrane protein; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site (779 aa)
        score_image   score_image   0.954
CDH23
cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (1114 aa)
        score_image   score_image   0.887
USH1C
Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) (899 aa)
        score_image   score_image   0.826
DFNB31
deafness, autosomal recessive 31 (907 aa)
        score_image   score_image   0.806
PCDH15
protocadherin-related 15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function (1957 aa)
        score_image   score_image   0.753
RAB38
RAB38, member RAS oncogene family; May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (211 aa)
            score_image   0.747
ACTA1
actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
        score_image   score_image   0.701
CALM1
calmodulin 1 (phosphorylase kinase, delta) (149 aa)
        score_image   score_image   0.677
IQCB1
IQ motif containing B1; Involved in ciliogenesis (By similarity) (598 aa)
      score_image     score_image   0.662
MYRIP
myosin VIIA and Rab interacting protein (859 aa)
        score_image   score_image   0.646
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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