node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPS2 | NIF3L1 | ENSP00000299259 | ENSP00000386394 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its a [...] | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.858 |
GCH1 | NIF3L1 | ENSP00000378890 | ENSP00000386394 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.688 |
MLX | MXD4 | ENSP00000246912 | ENSP00000337889 | MLX, MAX dimerization protein | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | 0.988 |
MLX | NIF3L1 | ENSP00000246912 | ENSP00000386394 | MLX, MAX dimerization protein | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.751 |
MLX | PKLR | ENSP00000246912 | ENSP00000339933 | MLX, MAX dimerization protein | pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) | 0.606 |
MXD4 | MLX | ENSP00000337889 | ENSP00000246912 | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | MLX, MAX dimerization protein | 0.988 |
MXD4 | NIF3L1 | ENSP00000337889 | ENSP00000386394 | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.754 |
MXD4 | PKLR | ENSP00000337889 | ENSP00000339933 | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) | 0.609 |
NIF3L1 | COPS2 | ENSP00000386394 | ENSP00000299259 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its a [...] | 0.858 |
NIF3L1 | GCH1 | ENSP00000386394 | ENSP00000378890 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.688 |
NIF3L1 | MLX | ENSP00000386394 | ENSP00000246912 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | MLX, MAX dimerization protein | 0.751 |
NIF3L1 | MXD4 | ENSP00000386394 | ENSP00000337889 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity) | 0.754 |
NIF3L1 | NT5DC1 | ENSP00000386394 | ENSP00000326858 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 5’-nucleotidase domain containing 1 | 0.644 |
NIF3L1 | PKLR | ENSP00000386394 | ENSP00000339933 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) | 0.660 |
NIF3L1 | PLXNB2 | ENSP00000386394 | ENSP00000352288 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | plexin B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrati [...] | 0.978 |
NIF3L1 | TACC1 | ENSP00000386394 | ENSP00000321703 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | transforming, acidic coiled-coil containing protein 1 | 0.966 |
NIF3L1 | TADA3 | ENSP00000386394 | ENSP00000307684 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | transcriptional adaptor 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.795 |
NIF3L1 | THOC7 | ENSP00000386394 | ENSP00000295899 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | THO complex 7 homolog (Drosophila); Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC [...] | 0.948 |
NT5DC1 | NIF3L1 | ENSP00000326858 | ENSP00000386394 | 5’-nucleotidase domain containing 1 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.644 |
PKLR | MLX | ENSP00000339933 | ENSP00000246912 | pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) | MLX, MAX dimerization protein | 0.606 |