splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C7orf34
chromosome 7 open reading frame 34 (147 aa)
Predicted Functional Partners:
ZBTB48
zinc finger and BTB domain containing 48; Binds to and regulates the J and/or S elements in MHC II promoter (688 aa)
0.796
HSF4
heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription (492 aa)
0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
C7orf34
HSF4
ENSP00000386450
ENSP00000264009
chromosome 7 open reading frame 34
heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription
0.472
C7orf34
ZBTB48
ENSP00000386450
ENSP00000366902
chromosome 7 open reading frame 34
zinc finger and BTB domain containing 48; Binds to and regulates the J and/or S elements in MHC II promoter
0.796
HSF4
C7orf34
ENSP00000264009
ENSP00000386450
heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription
chromosome 7 open reading frame 34
0.472
ZBTB48
C7orf34
ENSP00000366902
ENSP00000386450
zinc finger and BTB domain containing 48; Binds to and regulates the J and/or S elements in MHC II promoter
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: