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STRINGSTRING
ATP8A2 ATP8A2 CA8 CA8 VLDLR VLDLR UBC UBC AGK AGK WDR81 WDR81 CLN8 CLN8 RTN4RL2 RTN4RL2 TLCD2 TLCD2 SMYD4 SMYD4 RTN4RL1 RTN4RL1
"WDR81" - WD repeat domain 81 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
WDR81WD repeat domain 81 (1941 aa)    
Predicted Functional Partners:
CA8
carbonic anhydrase VIII; Does not have a carbonic anhydrase catalytic activity (290 aa)
            score_image   0.860
TLCD2
TLC domain containing 2 (264 aa)
            score_image   0.836
UBC
ubiquitin C (685 aa)
        score_image       0.815
SMYD4
SET and MYND domain containing 4 (804 aa)
            score_image   0.778
VLDLR
very low density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity) (873 aa)
            score_image   0.746
RTN4RL1
reticulon 4 receptor-like 1; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (441 aa)
            score_image   0.725
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2 (1188 aa)
            score_image   0.722
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death (286 aa)
            score_image   0.579
AGK
acylglycerol kinase; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (422 aa)
            score_image   0.552
RTN4RL2
reticulon 4 receptor-like 2; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (420 aa)
            score_image   0.551
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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