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STRINGSTRING
SPG20 SPG20 UEVLD UEVLD DNM1L DNM1L TRIM45 TRIM45 STAC STAC WAS WAS FCHSD2 FCHSD2 DNM3 DNM3 WASL WASL DNM1 DNM1 DNM2 DNM2
"FCHSD2" - FCH and double SH3 domains 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FCHSD2FCH and double SH3 domains 2 (740 aa)    
Predicted Functional Partners:
TRIM45
tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway (580 aa)
            score_image   0.815
WASL
Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa)
        score_image   score_image   0.780
UEVLD
UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination (471 aa)
            score_image   0.757
WAS
Wiskott-Aldrich syndrome; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (502 aa)
        score_image   score_image   0.747
SPG20
spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both (666 aa)
            score_image   0.729
STAC
SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction (402 aa)
            score_image   0.722
DNM1
dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (864 aa)
        score_image   score_image   0.671
DNM3
dynamin 3 (863 aa)
        score_image   score_image   0.671
DNM2
dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (870 aa)
        score_image   score_image   0.671
DNM1L
dynamin 1-like (736 aa)
        score_image   score_image   0.668
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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