node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNM1 | DNM2 | ENSP00000362014 | ENSP00000347890 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | 0.917 |
DNM1 | FCHSD2 | ENSP00000362014 | ENSP00000386722 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | FCH and double SH3 domains 2 | 0.671 |
DNM1 | WASL | ENSP00000362014 | ENSP00000223023 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression | 0.516 |
DNM1L | FCHSD2 | ENSP00000450399 | ENSP00000386722 | dynamin 1-like | FCH and double SH3 domains 2 | 0.668 |
DNM2 | DNM1 | ENSP00000347890 | ENSP00000362014 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | 0.917 |
DNM2 | FCHSD2 | ENSP00000347890 | ENSP00000386722 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | FCH and double SH3 domains 2 | 0.671 |
DNM2 | WASL | ENSP00000347890 | ENSP00000223023 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression | 0.961 |
DNM3 | FCHSD2 | ENSP00000350876 | ENSP00000386722 | dynamin 3 | FCH and double SH3 domains 2 | 0.671 |
FCHSD2 | DNM1 | ENSP00000386722 | ENSP00000362014 | FCH and double SH3 domains 2 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | 0.671 |
FCHSD2 | DNM1L | ENSP00000386722 | ENSP00000450399 | FCH and double SH3 domains 2 | dynamin 1-like | 0.668 |
FCHSD2 | DNM2 | ENSP00000386722 | ENSP00000347890 | FCH and double SH3 domains 2 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | 0.671 |
FCHSD2 | DNM3 | ENSP00000386722 | ENSP00000350876 | FCH and double SH3 domains 2 | dynamin 3 | 0.671 |
FCHSD2 | SPG20 | ENSP00000386722 | ENSP00000347314 | FCH and double SH3 domains 2 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.729 |
FCHSD2 | STAC | ENSP00000386722 | ENSP00000273183 | FCH and double SH3 domains 2 | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.722 |
FCHSD2 | TRIM45 | ENSP00000386722 | ENSP00000256649 | FCH and double SH3 domains 2 | tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway | 0.815 |
FCHSD2 | UEVLD | ENSP00000386722 | ENSP00000379500 | FCH and double SH3 domains 2 | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination | 0.757 |
FCHSD2 | WAS | ENSP00000386722 | ENSP00000365891 | FCH and double SH3 domains 2 | Wiskott-Aldrich syndrome; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria | 0.747 |
FCHSD2 | WASL | ENSP00000386722 | ENSP00000223023 | FCH and double SH3 domains 2 | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression | 0.780 |
SPG20 | FCHSD2 | ENSP00000347314 | ENSP00000386722 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | FCH and double SH3 domains 2 | 0.729 |
SPG20 | STAC | ENSP00000347314 | ENSP00000273183 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.756 |