KCMF1 protein (Homo sapiens) - STRING network view

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KCMF1

potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination (381 aa)

Predicted Functional Partners:

UBC

0.903

UBR4

0.682

THNSL2

0.639

UBE2D2

0.582

PSMC1

0.535

PSMD12

0.531

PSMC5

0.528

PSMD7

0.521

CLEC16A

0.516

SNRPD1

0.503

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLEC16A	KCMF1	ENSP00000387122	ENSP00000386738	C-type lectin domain family 16, member A	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	0.516
CLEC16A	THNSL2	ENSP00000387122	ENSP00000327323	C-type lectin domain family 16, member A	threonine synthase-like 2 (S. cerevisiae); Isoform 1- Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)	0.629
CLEC16A	UBC	ENSP00000387122	ENSP00000344818	C-type lectin domain family 16, member A	ubiquitin C	0.851
KCMF1	CLEC16A	ENSP00000386738	ENSP00000387122	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	C-type lectin domain family 16, member A	0.516
KCMF1	PSMC1	ENSP00000386738	ENSP00000261303	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	0.535
KCMF1	PSMC5	ENSP00000386738	ENSP00000310572	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	0.528
KCMF1	PSMD12	ENSP00000386738	ENSP00000348442	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	0.531
KCMF1	PSMD7	ENSP00000386738	ENSP00000219313	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	0.521
KCMF1	SNRPD1	ENSP00000386738	ENSP00000300413	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	small nuclear ribonucleoprotein D1 polypeptide 16kDa; May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA	0.503
KCMF1	THNSL2	ENSP00000386738	ENSP00000327323	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	threonine synthase-like 2 (S. cerevisiae); Isoform 1- Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)	0.639
KCMF1	UBC	ENSP00000386738	ENSP00000344818	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	ubiquitin C	0.903
KCMF1	UBE2D2	ENSP00000386738	ENSP00000381717	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	ubiquitin-conjugating enzyme E2D 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’-, as well as ’Lys-48’-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions ’Lys-21’ and/or ’Lys-22’ with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-prime [...]	0.582
KCMF1	UBR4	ENSP00000386738	ENSP00000364403	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	ubiquitin protein ligase E3 component n-recognin 4	0.682
PSMC1	KCMF1	ENSP00000261303	ENSP00000386738	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	0.535
PSMC1	PSMC5	ENSP00000261303	ENSP00000310572	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	0.999
PSMC1	PSMD12	ENSP00000261303	ENSP00000348442	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	0.999
PSMC1	PSMD7	ENSP00000261303	ENSP00000219313	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	0.999
PSMC1	UBC	ENSP00000261303	ENSP00000344818	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	ubiquitin C	0.999
PSMC5	KCMF1	ENSP00000310572	ENSP00000386738	proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination	0.528
PSMC5	PSMC1	ENSP00000310572	ENSP00000261303	proteasome (prosome, macropain) 26S subunit, ATPase, 5; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	0.999

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