Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
UBC UBC BAI3 BAI3 SKA1 SKA1 VPS54 VPS54 CCDC75 CCDC75 UPP2 UPP2 ANXA2R ANXA2R C4orf33 C4orf33 SMGA SMGA CCDC109B CCDC109B GBP5 GBP5
"CCDC75" - coiled-coil domain containing 75 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCDC75coiled-coil domain containing 75 (259 aa)    
Predicted Functional Partners:
C4orf33
chromosome 4 open reading frame 33 (199 aa)
            score_image   0.660
UBC
ubiquitin C (685 aa)
        score_image       0.620
UPP2
uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(’)-deoxyuridine as substrates (374 aa)
            score_image   0.618
BAI3
brain-specific angiogenesis inhibitor 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma (1522 aa)
        score_image       0.612
CCDC109B
coiled-coil domain containing 109B (336 aa)
            score_image   0.589
SMGA
Protein Smaug homolog 1 (629 aa)
            score_image   0.482
SKA1
spindle and kinetochore associated complex subunit 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubu [...] (255 aa)
      score_image         0.480
ANXA2R
annexin A2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation (193 aa)
            score_image   0.459
VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (977 aa)
        score_image       0.455
GBP5
guanylate binding protein 5; Stimulates the NLRP3 inflammasome assembly upon bacterial challenge (586 aa)
            score_image   0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (56%)