| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABRA | KIAA0922 | ENSP00000311436 | ENSP00000386787 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | KIAA0922 | 0.485 |
| ABRA | RALGAPB | ENSP00000311436 | ENSP00000262879 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.495 |
| ABRA | YTHDF1 | ENSP00000311436 | ENSP00000359364 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | YTH domain family, member 1 | 0.485 |
| ABRA | YTHDF2 | ENSP00000311436 | ENSP00000362918 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | YTH domain family, member 2 | 0.485 |
| CCDC109B | KIAA0922 | ENSP00000378145 | ENSP00000386787 | coiled-coil domain containing 109B | KIAA0922 | 0.581 |
| CXorf59 | DLEC1 | ENSP00000324767 | ENSP00000308597 | chromosome X open reading frame 59 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | 0.509 |
| CXorf59 | KIAA0922 | ENSP00000324767 | ENSP00000386787 | chromosome X open reading frame 59 | KIAA0922 | 0.501 |
| DDX1 | FPGS | ENSP00000233084 | ENSP00000362344 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates | 0.417 |
| DDX1 | KIAA0922 | ENSP00000233084 | ENSP00000386787 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | KIAA0922 | 0.654 |
| DDX1 | UBC | ENSP00000233084 | ENSP00000344818 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | ubiquitin C | 0.927 |
| DLEC1 | CXorf59 | ENSP00000308597 | ENSP00000324767 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | chromosome X open reading frame 59 | 0.509 |
| DLEC1 | KIAA0922 | ENSP00000308597 | ENSP00000386787 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | KIAA0922 | 0.520 |
| FPGS | DDX1 | ENSP00000362344 | ENSP00000233084 | folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.417 |
| FPGS | KIAA0922 | ENSP00000362344 | ENSP00000386787 | folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates | KIAA0922 | 0.674 |
| FPGS | UBC | ENSP00000362344 | ENSP00000344818 | folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates | ubiquitin C | 0.909 |
| KIAA0922 | ABRA | ENSP00000386787 | ENSP00000311436 | KIAA0922 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | 0.485 |
| KIAA0922 | CCDC109B | ENSP00000386787 | ENSP00000378145 | KIAA0922 | coiled-coil domain containing 109B | 0.581 |
| KIAA0922 | CXorf59 | ENSP00000386787 | ENSP00000324767 | KIAA0922 | chromosome X open reading frame 59 | 0.501 |
| KIAA0922 | DDX1 | ENSP00000386787 | ENSP00000233084 | KIAA0922 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.654 |
| KIAA0922 | DLEC1 | ENSP00000386787 | ENSP00000308597 | KIAA0922 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | 0.520 |
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