DYSF protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

DYSF

dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) (2119 aa)

Predicted Functional Partners:

ANO5

0.902

CAPN3

0.892

CAV3

0.815

MMD2

0.758

SGCA

0.751

SGCB

0.750

PSMG3

0.745

SGCG

0.718

ANXA2

0.696

ANXA1

0.693

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO5	CAPN3	ENSP00000315371	ENSP00000380349	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	0.700
ANO5	CAV3	ENSP00000315371	ENSP00000341940	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress	0.499
ANO5	DYSF	ENSP00000315371	ENSP00000386881	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.902
ANO5	MMD2	ENSP00000315371	ENSP00000384690	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	monocyte to macrophage differentiation-associated 2	0.860
ANO5	PSMG3	ENSP00000315371	ENSP00000252329	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	proteasome (prosome, macropain) assembly chaperone 3; Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes	0.749
ANO5	SGCA	ENSP00000315371	ENSP00000262018	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.519
ANO5	SGCB	ENSP00000315371	ENSP00000370839	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.609
ANO5	SGCG	ENSP00000315371	ENSP00000218867	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.400
ANXA1	DYSF	ENSP00000257497	ENSP00000386881	annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.693
ANXA2	DYSF	ENSP00000346032	ENSP00000386881	annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in heat-stress response (By similarity)	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.696
CAPN3	ANO5	ENSP00000380349	ENSP00000315371	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	0.700
CAPN3	CAV3	ENSP00000380349	ENSP00000341940	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress	0.507
CAPN3	DYSF	ENSP00000380349	ENSP00000386881	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.892
CAPN3	SGCA	ENSP00000380349	ENSP00000262018	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.729
CAPN3	SGCB	ENSP00000380349	ENSP00000370839	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.748
CAPN3	SGCG	ENSP00000380349	ENSP00000218867	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.758
CAV3	ANO5	ENSP00000341940	ENSP00000315371	caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress	anoctamin 5; Does not exhibit calcium-activated chloride channel (CaCC) activity	0.499
CAV3	CAPN3	ENSP00000341940	ENSP00000380349	caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress	calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease	0.507
CAV3	DYSF	ENSP00000341940	ENSP00000386881	caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.815
CAV3	SGCA	ENSP00000341940	ENSP00000262018	caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.845

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