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STRINGSTRING
TMEM88B TMEM88B KLHDC1 KLHDC1 FBXO42 FBXO42 TMEM132C TMEM132C CORO2B CORO2B MEGF11 MEGF11 KLHDC10 KLHDC10 GULP1 GULP1 KLHDC2 KLHDC2 EMILIN1 EMILIN1 CCDC136 CCDC136
"MEGF11" - multiple EGF-like-domains 11 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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MEGF11multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity) (1044 aa)    
Predicted Functional Partners:
EMILIN1
elastin microfibril interfacer 1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (1016 aa)
            score_image   0.758
TMEM88B
transmembrane protein 88B (163 aa)
            score_image   0.757
GULP1
GULP, engulfment adaptor PTB domain containing 1 (304 aa)
        score_image   score_image   0.737
TMEM132C
transmembrane protein 132C (1108 aa)
            score_image   0.648
KLHDC1
kelch domain containing 1 (406 aa)
      score_image     score_image   0.631
KLHDC10
kelch domain containing 10 (442 aa)
      score_image     score_image   0.612
KLHDC2
kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding (406 aa)
      score_image     score_image   0.606
CCDC136
coiled-coil domain containing 136 (1154 aa)
            score_image   0.601
CORO2B
coronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure (480 aa)
      score_image         0.585
FBXO42
F-box protein 42; Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (717 aa)
      score_image         0.585
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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