| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG13 | TBC1D14 | ENSP00000432412 | ENSP00000386921 | autophagy related 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.570 |
| ATG13 | ULK1 | ENSP00000432412 | ENSP00000324560 | autophagy related 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation | unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] | 0.999 |
| C7orf26 | TBC1D14 | ENSP00000340220 | ENSP00000386921 | chromosome 7 open reading frame 26 | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.508 |
| MRPL11 | TBC1D14 | ENSP00000308897 | ENSP00000386921 | mitochondrial ribosomal protein L11 | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.559 |
| MRPL11 | TRAPPC10 | ENSP00000308897 | ENSP00000291574 | mitochondrial ribosomal protein L11 | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.508 |
| RAB11A | RAB11B | ENSP00000261890 | ENSP00000333547 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | 0.949 |
| RAB11A | RAB11FIP3 | ENSP00000261890 | ENSP00000262305 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 3 (class II) | 0.999 |
| RAB11A | TBC1D14 | ENSP00000261890 | ENSP00000386921 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.963 |
| RAB11A | TFRC | ENSP00000261890 | ENSP00000353224 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | transferrin receptor (p90, CD71); Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin f [...] | 0.725 |
| RAB11A | TRAPPC10 | ENSP00000261890 | ENSP00000291574 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.777 |
| RAB11B | RAB11A | ENSP00000333547 | ENSP00000261890 | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | 0.949 |
| RAB11B | RAB11FIP3 | ENSP00000333547 | ENSP00000262305 | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | RAB11 family interacting protein 3 (class II) | 0.989 |
| RAB11B | TBC1D14 | ENSP00000333547 | ENSP00000386921 | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.761 |
| RAB11B | TRAPPC10 | ENSP00000333547 | ENSP00000291574 | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.765 |
| RAB11FIP3 | RAB11A | ENSP00000262305 | ENSP00000261890 | RAB11 family interacting protein 3 (class II) | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | 0.999 |
| RAB11FIP3 | RAB11B | ENSP00000262305 | ENSP00000333547 | RAB11 family interacting protein 3 (class II) | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | 0.989 |
| RAB11FIP3 | TBC1D14 | ENSP00000262305 | ENSP00000386921 | RAB11 family interacting protein 3 (class II) | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.690 |
| SNX18 | TBC1D14 | ENSP00000317332 | ENSP00000386921 | sorting nexin 18; May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | 0.540 |
| TBC1D14 | ATG13 | ENSP00000386921 | ENSP00000432412 | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | autophagy related 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation | 0.570 |
| TBC1D14 | C7orf26 | ENSP00000386921 | ENSP00000340220 | TBC1 domain family, member 14; Negative regulator of starvation-induced autophagosome formation | chromosome 7 open reading frame 26 | 0.508 |
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