splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERF2
small EDRK-rich factor 2 (170 aa)
Predicted Functional Partners:
HTT
huntingtin; May play a role in microtubule-mediated transport or vesicle function (3142 aa)
0.574
GEMIN2
gem (nuclear organelle) associated protein 2; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus (280 aa)
0.436
RHOXF2
Rhox homeobox family, member 2 (288 aa)
0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
GEMIN2
SERF2
ENSP00000308533
ENSP00000387187
gem (nuclear organelle) associated protein 2; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus
small EDRK-rich factor 2
0.436
HTT
SERF2
ENSP00000347184
ENSP00000387187
huntingtin; May play a role in microtubule-mediated transport or vesicle function
small EDRK-rich factor 2
0.574
RHOXF2
SERF2
ENSP00000360441
ENSP00000387187
Rhox homeobox family, member 2
small EDRK-rich factor 2
0.414
SERF2
GEMIN2
ENSP00000387187
ENSP00000308533
small EDRK-rich factor 2
gem (nuclear organelle) associated protein 2; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus
0.436
SERF2
HTT
ENSP00000387187
ENSP00000347184
small EDRK-rich factor 2
huntingtin; May play a role in microtubule-mediated transport or vesicle function
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: