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STRINGSTRING
TOMM40L TOMM40L FUBP1 FUBP1 TOMM40 TOMM40 TOMM22 TOMM22 SAMM50 SAMM50 IMMT IMMT DISC1 DISC1 CHCHD3 CHCHD3 MTX2 MTX2 CHCHD6 CHCHD6 MINOS1 MINOS1
"IMMT" - inner membrane protein, mitochondrial in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IMMTinner membrane protein, mitochondrial (758 aa)    
Predicted Functional Partners:
SAMM50
sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) (469 aa)
        score_image   score_image   0.998
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (227 aa)
        score_image   score_image   0.992
MTX2
metaxin 2; Involved in transport of proteins into the mitochondrion (263 aa)
        score_image   score_image   0.949
MINOS1
mitochondrial inner membrane organizing system 1; May play a role in mitochondrial architecture (By similarity) (78 aa)
      score_image score_image   score_image   0.916
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption (235 aa)
        score_image   score_image   0.914
TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (142 aa)
        score_image   score_image   0.830
FUBP1
far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (644 aa)
        score_image   score_image   0.827
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast); Channel-forming protein essential for import of protein precursors into mitochondria (By similarity) (361 aa)
        score_image   score_image   0.814
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like; Potential channel-forming protein implicated in import of protein precursors into mitochondria (By similarity) (308 aa)
        score_image   score_image   0.773
DISC1
disrupted in schizophrenia 1 (755 aa)
        score_image   score_image   0.766
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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