node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHCHD3 | IMMT | ENSP00000262570 | ENSP00000387262 | coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription | inner membrane protein, mitochondrial | 0.992 |
CHCHD3 | MINOS1 | ENSP00000262570 | ENSP00000325562 | coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription | mitochondrial inner membrane organizing system 1; May play a role in mitochondrial architecture (By similarity) | 0.809 |
CHCHD3 | MTX2 | ENSP00000262570 | ENSP00000249442 | coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription | metaxin 2; Involved in transport of proteins into the mitochondrion | 0.701 |
CHCHD3 | SAMM50 | ENSP00000262570 | ENSP00000345445 | coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.992 |
CHCHD6 | DISC1 | ENSP00000290913 | ENSP00000355593 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | disrupted in schizophrenia 1 | 0.833 |
CHCHD6 | IMMT | ENSP00000290913 | ENSP00000387262 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | inner membrane protein, mitochondrial | 0.914 |
CHCHD6 | MTX2 | ENSP00000290913 | ENSP00000249442 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | metaxin 2; Involved in transport of proteins into the mitochondrion | 0.569 |
CHCHD6 | SAMM50 | ENSP00000290913 | ENSP00000345445 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.810 |
DISC1 | CHCHD6 | ENSP00000355593 | ENSP00000290913 | disrupted in schizophrenia 1 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.833 |
DISC1 | IMMT | ENSP00000355593 | ENSP00000387262 | disrupted in schizophrenia 1 | inner membrane protein, mitochondrial | 0.766 |
FUBP1 | IMMT | ENSP00000359804 | ENSP00000387262 | far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | inner membrane protein, mitochondrial | 0.827 |
IMMT | CHCHD3 | ENSP00000387262 | ENSP00000262570 | inner membrane protein, mitochondrial | coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription | 0.992 |
IMMT | CHCHD6 | ENSP00000387262 | ENSP00000290913 | inner membrane protein, mitochondrial | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.914 |
IMMT | DISC1 | ENSP00000387262 | ENSP00000355593 | inner membrane protein, mitochondrial | disrupted in schizophrenia 1 | 0.766 |
IMMT | FUBP1 | ENSP00000387262 | ENSP00000359804 | inner membrane protein, mitochondrial | far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | 0.827 |
IMMT | MINOS1 | ENSP00000387262 | ENSP00000325562 | inner membrane protein, mitochondrial | mitochondrial inner membrane organizing system 1; May play a role in mitochondrial architecture (By similarity) | 0.916 |
IMMT | MTX2 | ENSP00000387262 | ENSP00000249442 | inner membrane protein, mitochondrial | metaxin 2; Involved in transport of proteins into the mitochondrion | 0.949 |
IMMT | SAMM50 | ENSP00000387262 | ENSP00000345445 | inner membrane protein, mitochondrial | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.998 |
IMMT | TOMM22 | ENSP00000387262 | ENSP00000216034 | inner membrane protein, mitochondrial | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | 0.830 |
IMMT | TOMM40 | ENSP00000387262 | ENSP00000252487 | inner membrane protein, mitochondrial | translocase of outer mitochondrial membrane 40 homolog (yeast); Channel-forming protein essential for import of protein precursors into mitochondria (By similarity) | 0.814 |