RAB6C protein (Homo sapiens) - STRING network view

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RAB6C

RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa)

Predicted Functional Partners:

VPS53

0.915

TP53

0.845

YKT6

0.792

ARL1

0.782

TBC1D5

0.782

ERC2

0.778

VPS54

0.768

VPS35

0.767

GDI1

0.755

GDI2

0.755

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL1	RAB6C	ENSP00000261636	ENSP00000387307	ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.782
ERC2	RAB6C	ENSP00000288221	ENSP00000387307	ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.778
GDI1	RAB6C	ENSP00000394071	ENSP00000387307	GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.755
GDI1	YKT6	ENSP00000394071	ENSP00000223369	GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them	YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity	0.529
GDI2	RAB6C	ENSP00000369538	ENSP00000387307	GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.755
RAB6C	ARL1	ENSP00000387307	ENSP00000261636	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus	0.782
RAB6C	ERC2	ENSP00000387307	ENSP00000288221	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ	0.778
RAB6C	GDI1	ENSP00000387307	ENSP00000394071	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them	0.755
RAB6C	GDI2	ENSP00000387307	ENSP00000369538	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them	0.755
RAB6C	TBC1D5	ENSP00000387307	ENSP00000402935	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s)	0.782
RAB6C	TP53	ENSP00000387307	ENSP00000269305	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.845
RAB6C	VPS35	ENSP00000387307	ENSP00000299138	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.767
RAB6C	VPS53	ENSP00000387307	ENSP00000401435	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	vacuolar protein sorting 53 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.915
RAB6C	VPS54	ENSP00000387307	ENSP00000272322	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.768
RAB6C	YKT6	ENSP00000387307	ENSP00000223369	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity	0.792
TBC1D5	RAB6C	ENSP00000402935	ENSP00000387307	TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s)	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.782
TBC1D5	VPS35	ENSP00000402935	ENSP00000299138	TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s)	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.791
TP53	RAB6C	ENSP00000269305	ENSP00000387307	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.845
VPS35	RAB6C	ENSP00000299138	ENSP00000387307	vacuolar protein sorting 35 homolog (S. cerevisiae)	RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression	0.767
VPS35	TBC1D5	ENSP00000299138	ENSP00000402935	vacuolar protein sorting 35 homolog (S. cerevisiae)	TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s)	0.791

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