Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (1990 aa) | ||||||||||||
Predicted Functional Partners:
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 | DLG4 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa) |
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0.874 | |||||||||
 | KIRREL3 | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) (778 aa) |
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0.749 | |||||||||
 | KIRREL2 | kin of IRRE like 2 (Drosophila) (708 aa) |
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0.749 | |||||||||
 | KIRREL | kin of IRRE like (Drosophila); Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity) (757 aa) |
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0.749 | |||||||||
 | NEURL1B | neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands (555 aa) |
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0.585 | |||||||||
 | NEURL | neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity) (574 aa) |
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0.585 | |||||||||
 | FOXN3 | forkhead box N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (490 aa) |
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0.533 | |||||||||
 | CAMSAP1 | calmodulin regulated spectrin-associated protein 1 (1602 aa) |
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0.506 | ||||||||||
 | RTN4RL1 | reticulon 4 receptor-like 1; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (441 aa) |
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0.499 | |||||||||
 | XKR7 | XK, Kell blood group complex subunit-related family, member 7 (579 aa) |
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0.495 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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